著者

矢尾板 啓 伊藤 修 有馬 秀二 遠藤 好美 竹内 和久 尾股 健 伊藤 貞嘉

出版者

社団法人 日本腎臓学会

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.41, no.7, pp.697-703, 1999

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We investigated the direct effect of adenosine on afferent arterioles (Af-Arts) and the receptor subtype that mediates the constrictor or dilator action of adenosine . Af-Arts were isolated from the superficial cortex of rabbit kidney and perfused in vitro. Adenosine added to either the lumen or bath constricted the Af-Arts in a dose dependent manner. This constriction was blocked by the A1 receptor antagonist, 6-oxo-3- (2-phenylpyrazole (1, 5-a) pyridin-3-yl) -1(6H) -pyridazinebutyric acid (FK838) or 8-cyclopentyl-1, 3 - dipropylxanthine (DPCPX). We also examined the effect of adenosine on preconstricted Af-Arts with norepinephrine. Adenosine added to either the lumen or bath further constricted the preconstricted Af-Arts. In the presence of FK838, adenosine added to either the lumen or bath dilated the preconstricted Af-Arts, but in a different dose dependent manner. Adenosine induced dilation was inhibited by the A<SUB>2</SUB> receptor antagonist, 3, 7-dimetyl-1- propargylxanthine (DMPX). These data indicate that adenosine constricts Af-Arts via A<SUB>1</SUB> receptors and that adenosine dilates preconstricted Af-Arts via A<SUB>2</SUB> receptors when A<SUB>1</SUB> receptors are blocked.