文献一覧: 尾股健 (著者)

1 0 0 0 レニン分泌の密集斑機構とプロスタグランジン

著者: 伊藤貞嘉阿部圭志尾股健保嶋実吉永馨
出版者: 社団法人日本腎臓学会
雑誌: 日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日: vol.30, no.1, pp.85-90, 1988

To examine the role of prostaglandins (PGs) in the macula densa mechanism of renin release, rabbit afferent arteriole (Af) alone and afferent arteriole with macula densa attached (Af+MD) were microdissected and incubated consecutively. Hourly renin release rate from a single Af (or Af+MD) was calculated and expressed as ngAI·h-1·Af-1 (or Af+MD-1)/h (where AI is angiotensin I). Basal renin release rate from Af was 0.84±0.14ngAI·h-1·Af-1/h (X±SEM, n=23) and remained stable throughout the incubations. Basal renin release rate from Af+MD was 0.33±0.04ngAI·h-1Af+MD-1/h (n=17), which was significantly lower (p<0.01) than that from Af. When furosemide (1.5 mM) was added to Af, no significant change in renin release rate was observed. However, when furosemide was added to Af+MD, renin release rate increased from 0.40±0.05 to 1.59±0.15ngAI·h-1·Af+MD-1/h (n=10, p<0.01). After the pretreatment with indomethacin, a cyclooxygenase inhibitor, furosemide still increased renin release rate from 0.17±0.02 to 0.56±0.09 ng AI·h-1·Af+MD-1/h (n=5, p<0.05) ; however, indomethacin pretreatment reduced both basal and furosemide-stimulated renin release rate (p<0.05). In the presence of PGI2 (10 μM), renin release rate from Af increased from 0.45±0.14 to 1.49±0.53 ng AI·h-1·AN/h (n=9, p<0.05), and further increased to 4.50±1.24 ng AI·h-1·Af-1/h (p<0.02) after removal from PGI2. When PGE2 (10 μM) was added to Af+MD, renin release rate increased from 0.54±0.09 to 1.26±0.24ng AI·h-1Af+MD-1/h (n=8, p< 0.05). However PGE2 had no effect on renin release rate from Af alone. We concluded that (1) the prostaglandin system may be a modulating factor of response in the macula densa mechanism of renin release, (2) PGI2 has direct action on renin release from affer-ent arteriole, and (3) PGE2 may participate in the control of renin release through the action on the macula densa.

2020-10-07 11:22:02
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1 0 0 0 腎輸入細動脈におけるアデノシンの作用

著者: 矢尾板啓伊藤修有馬秀二遠藤好美竹内和久尾股健伊藤貞嘉
出版者: 社団法人日本腎臓学会
雑誌: 日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日: vol.41, no.7, pp.697-703, 1999

We investigated the direct effect of adenosine on afferent arterioles (Af-Arts) and the receptor subtype that mediates the constrictor or dilator action of adenosine . Af-Arts were isolated from the superficial cortex of rabbit kidney and perfused in vitro. Adenosine added to either the lumen or bath constricted the Af-Arts in a dose dependent manner. This constriction was blocked by the A1 receptor antagonist, 6-oxo-3- (2-phenylpyrazole (1, 5-a) pyridin-3-yl) -1(6H) -pyridazinebutyric acid (FK838) or 8-cyclopentyl-1, 3 - dipropylxanthine (DPCPX). We also examined the effect of adenosine on preconstricted Af-Arts with norepinephrine. Adenosine added to either the lumen or bath further constricted the preconstricted Af-Arts. In the presence of FK838, adenosine added to either the lumen or bath dilated the preconstricted Af-Arts, but in a different dose dependent manner. Adenosine induced dilation was inhibited by the A2 receptor antagonist, 3, 7-dimetyl-1- propargylxanthine (DMPX). These data indicate that adenosine constricts Af-Arts via A1 receptors and that adenosine dilates preconstricted Af-Arts via A2 receptors when A1 receptors are blocked.

2020-10-07 11:22:02
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