著者

尾崎 雅彦 南浦 純一 北島 良則 溝上 宗二 竹内 和久 畠中 勝則

出版者

公益社団法人日本船舶海洋工学会

雑誌

日本造船学会論文集 (ISSN:05148499)

巻号頁・発行日

no.187, pp.185-192, 2000-06

被引用文献数

3

---

Ocean sequestration of the captured CO_2 from fossil fuel burning is a possible option to mitigate the increase of CO_2 concentration in the atmosphere. It can isolate huge amount of CO_2 from the atmosphere for long time in relatively low cost, if it is acceptable from the viewpoint of the oceanic environmental impact. The dissolution type treated in this paper is based on the idea that CO_2 dissolved and sufficiently diluted in seawater does no more harms than slightly increasing the concentration of CO_2 already contained in the seawater. The concept of CO_2 dispersion in the ocean depths by ship is a promising implementation for the efficient dilution. That is, liquefied CO_2 is delivered by ship to the site and injected into ocean depths of 1,000 to 2,500m with a suspended and towed pipe by a slowly moving ship. The constant movement of releasing point of CO_2 causes no stagnation and accumulation of CO_2 in seawater. The released CO_2 will form plenty of droplets, and then they rise gently due to the buoyancy, while reducing in the size to disappear by dissolution in the ambient seawater. Since the turbulent diffusion in the intermediate ocean is dominant horizontally, use of the vertical journey of CO_2 droplets will be very effective for the initial dilution. Thus, authors have good prospects for the dilution ratio of one to a hundred thousands in a couple of hours after injection on an engineering realistic scale, by means that the initial size of droplets is controlled. Drop formations from a fixed nozzle are investigated referring the common knowledge on textbooks. And the possibility of generating relatively large size of droplets from a moving nozzle is experimentally studied. As a result, it is found that the horizontal nozzle towed by the slowly moving ship is promising for the control of the drop formations in a realistic scale .

著者

高橋 征三 藤原 正子 高橋 信行 竹内 和久

出版者

東北大学

雑誌

挑戦的萌芽研究

巻号頁・発行日

2012-04-01

---

腎臓病患者の血中のビオチン(ビタミンH)濃度を測定したところ、健常者より高値であることを見出した。腎臓機能の低下した患者はビオチンだけでなくその代謝物を尿に排泄できずに血中に蓄積していることを意味している。この代謝物はビタミンとしての活性がないだけでなく、元のビオチンの活性を妨げることが言われている。腎臓病患者にとって慢性的な代謝物の蓄積は、病態を進行させるなど深刻な影響を与える。そこで活性のある元のビオチンと活性のなくなったビオチン代謝物を区別して測定する方法を開発した。さらにNMR(磁気共鳴)法を用いて慢性患者に特有の代謝を解明することにより、治療への道を拓きたい。

著者

矢尾板 啓 伊藤 修 有馬 秀二 遠藤 好美 竹内 和久 尾股 健 伊藤 貞嘉

出版者

社団法人 日本腎臓学会

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.41, no.7, pp.697-703, 1999

---

We investigated the direct effect of adenosine on afferent arterioles (Af-Arts) and the receptor subtype that mediates the constrictor or dilator action of adenosine . Af-Arts were isolated from the superficial cortex of rabbit kidney and perfused in vitro. Adenosine added to either the lumen or bath constricted the Af-Arts in a dose dependent manner. This constriction was blocked by the A1 receptor antagonist, 6-oxo-3- (2-phenylpyrazole (1, 5-a) pyridin-3-yl) -1(6H) -pyridazinebutyric acid (FK838) or 8-cyclopentyl-1, 3 - dipropylxanthine (DPCPX). We also examined the effect of adenosine on preconstricted Af-Arts with norepinephrine. Adenosine added to either the lumen or bath further constricted the preconstricted Af-Arts. In the presence of FK838, adenosine added to either the lumen or bath dilated the preconstricted Af-Arts, but in a different dose dependent manner. Adenosine induced dilation was inhibited by the A<SUB>2</SUB> receptor antagonist, 3, 7-dimetyl-1- propargylxanthine (DMPX). These data indicate that adenosine constricts Af-Arts via A<SUB>1</SUB> receptors and that adenosine dilates preconstricted Af-Arts via A<SUB>2</SUB> receptors when A<SUB>1</SUB> receptors are blocked.