文献一覧: 野島庄七 (著者)

2 0 0 0 OA An Enantioselective Synthesis of Platelet-Activating Factors, Their Enantiomers, and Their Analogues from D-and L-Tartaric Acids

著者: 大野雅二藤田かがり中井久雄小林進井上圭三野島庄七
出版者: 公益社団法人日本薬学会
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: vol.33, no.2, pp.572-582, 1985-02-25 (Released:2008-03-31)
参考文献数: 21
被引用文献数: 41 49

Acetyl glyceryl ether phosphorylcholines (platelet-activating factors ; PAFs), their enantiomers, and their analogues were efficiently synthesized in a stereochemically unambiguous manner starting from D-and L-tartaric acids as chiral synthons. The enantiomer of C16-PAF (S-comfiguration) showed far less activity than the natural PAF (R-configuration), and the N-methylpiperidine and N-methylpyrrolidine analogues were found to possess much higher activity than natural C16-PAF.