著者

金坂 伊須萌 金山 明子 中西 康大 鈴木 崇嗣 金子 明寛 小林 寅喆

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.3, pp.100-105, 2015 (Released:2015-12-25)

参考文献数

18

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We conducted a study about the antimicrobial susceptibility to ceftriaxone(CTRX)and prevalence of the genes cfxA/cfxA2 of clinical isolated Prevotella strains. Furthermore, we performed in vitro study for effects on the antibiotic treatment by mixed culture of β-lactamase producing Prevotella and Streptococcus mitis. All Prevotella isolates resistant to CTRX(MIC ≧32μg/mL)were found possess the cfxA/cfxA2. Prevalence of cfxA/cfxA2 of Prevotella isolates classified as susceptible by CLSI guidelines showing a MIC of ≦0.5μg/mL were less than 25% and a MIC of 1-16μg/mL were more than 73%. Viable cells of S. mitis showed more than 99% decrease in culture broth with CTRX at a concentration of 5μg/mL for up to 8 hours. In mixed culture of ESBL producing Prevotella oralis and S. mitis, viable cells of S. mitis was increased slightly in the presence of CTRX. The decrease of viable counts in S. mitis was not seen in the case of mixed culture of ESBL-producing P. oralis and S. mitis in the presence of CTRX at a concentration of 5μg/mL for up to 8 hours.   In conclusion, the cases of mixed infection with Prevotella and Oral Streptococci, it was suggested that the Prevotella producing ESBL caused an indirect pathogen for odontogenic infection.