著者

金森 耀平 村上 賢 松井 徹 舟場 正幸

出版者

日本微量栄養素学会

雑誌

微量栄養素研究 (ISSN:13462334)

巻号頁・発行日

vol.31, pp.88-98, 2014-12-15 (Released:2022-12-28)

参考文献数

76

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The liver-derived peptide hormone hepcidin is a master regulator of systemic iron homeostatis. Hepcidin binds to an iron exporter ferroportin expressing on the basolateral membrane of enterocytes and induces the internalization and degradation of ferroportin, leading to a decrease in intestinal iron absorption. Various stimuli such as body iron stores, inflammation, erythropoiesis, and hypoxia affect hepcidin expression through the transcriptional regulation. This mini-review summarizes current understandings on the factors affecting hepcidin expression.