著者

森田 裕子 水村 亮介 橘 義貴 金澤 秀子

出版者

The Japan Society for Analytical Chemistry

雑誌

分析化学 = Japan analyst (ISSN:05251931)

巻号頁・発行日

vol.62, no.6, pp.541-545, 2013-06-05

参考文献数

14

被引用文献数

2

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Cation exchange resins (calcium polystyrene sulfonate, Ca-resin and sodium polystyrene sulfonate, Na-resin) have been used as agents to improve hyperkerlemia. For removing ¹³⁷Cs from the human body, the adsorption ability of the resin for ¹³⁷Cs was examined and evaluated. Resin (0.03 g) and ¹³⁷Cs (ca.1 kBq) were introduced into 3 mL of water, the Japanese Pharmacopoeia 1st fluid for a dissolution test (pH 1.2) and 2nd fluid (pH 6.8), respectively, and shaken. After 1-3 hours, the ¹³⁷Cs adsorption (%) of Na-resin was 99% in water, 60% in a pH 1.2 fluid and, 66% in a pH 6.8 fluid. By adding potassium, the ¹³⁷Cs adsorption (%) of Ca-resin was reduced. However, the ¹³⁷Cs adsorption (%) of Na-resin was almost unchanged. These results show that both resins have adsorption ability for ¹³⁷Cs in the stomach and the intestines. Therefore, the proposed method will be an effective means in the case of a radiological emergency due to ¹³⁷Cs.

著者

芳川 満輝 内田 亮 黒木 巽 三熊 敏靖 蛭田 勇樹 永田 佳子 金澤 秀子

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.65, no.4, pp.173-179, 2016-04-05 (Released:2016-05-10)

参考文献数

11

被引用文献数

1

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Recently, the need for the analysis of psychotropic drugs has increased. With the revision of the medical treatment fees in FY2014, facilities that can be calculated in those case that could identify the drugs responsible for acute drug poisoning of a patient by instrumental analysis, including HPLC analysis, were expanded from only advanced emergency medical care centers (30 facilities nationwide) to emergency medical care centers (263 facilities nationwide). Since the responsible drugs can include barbiturate drugs used as antiepileptics and tricyclic drugs used as antidepressants, methods to analyze psychotropic drugs are needed. Moreover, in emergency medicine, it is necessary to quickly identify the cause of acute drug poisoning. Ultra-high-speed HPLC has become increasingly popular in analytical research fields. In this study, we investigated the analysis of psychotropic drugs using an ultra-high-speed HPLC system. The HPLC utilized in this study was a ChromasterUltra Rs system (Hitachi, Tokyo, Japan) equipped with a photodiode array detector. Using a LaChrom Ultra C18 column (particle size; 1.9 μm) as the analytical column, rapid and simultaneous analysis of 14 psychotropic drugs (five barbiturates, three benzodiazepines, five tri- and tetracyclic antidepressants, and trazodone) was achieved within 5 min.

著者

中村 拓己 浅田 絵美 永田 佳子 金澤 秀子

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.52, no.9, pp.769-773, 2003 (Released:2004-01-30)

参考文献数

12

被引用文献数

6 5

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市販品の緑茶中の主要成分であるカテキン類は,その製茶工程あるいは殺菌工程で熱異性化が起こることが知られており,緑茶カテキン類のうち含有量の最も多いとされているエピガロカテキンガレート(EGCG)は,ペットボトル飲料においては,その熱異性化体であるガロカテキンガレート(GCG)とほぼ1 : 1の割合で存在していた.また,抽出温度を変化させた実験から,緑茶はおよそ80℃ 付近から,熱異性化が起こり,抽出温度が98℃ となるとEGCGの熱異性化は更に進むことが確認された.更に,これらカテキン類のシトクロームP450(CYP)3A4代謝系に対する活性について検討した結果,構造中にガレートを有するカテキン類であるEGCG,GCG,エピカテキンガレート(ECG)のほうがガレート構造を持たないカテキン類と比較して阻害効果が大きいことが明らかとなった.したがって,CYP3A4代謝系に対するカテキン類の阻害効果は,ガレート構造の有無により大きく影響されることが示唆された.

著者

森田 裕子 水村 亮介 橘 義貴 金澤 秀子

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.62, no.6, pp.541-545, 2013-06-05 (Released:2013-06-27)

参考文献数

14

被引用文献数

2

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Cation exchange resins (calcium polystyrene sulfonate, Ca-resin and sodium polystyrene sulfonate, Na-resin) have been used as agents to improve hyperkerlemia. For removing 137Cs from the human body, the adsorption ability of the resin for 137Cs was examined and evaluated. Resin (0.03 g) and 137Cs (ca.1 kBq) were introduced into 3 mL of water, the Japanese Pharmacopoeia 1st fluid for a dissolution test (pH 1.2) and 2nd fluid (pH 6.8), respectively, and shaken. After 1-3 hours, the 137Cs adsorption (%) of Na-resin was 99% in water, 60% in a pH 1.2 fluid and, 66% in a pH 6.8 fluid. By adding potassium, the 137Cs adsorption (%) of Ca-resin was reduced. However, the 137Cs adsorption (%) of Na-resin was almost unchanged. These results show that both resins have adsorption ability for 137Cs in the stomach and the intestines. Therefore, the proposed method will be an effective means in the case of a radiological emergency due to 137Cs.