著者

長友 暁史 西田 典永

出版者

食品化学新聞社

雑誌

Food style 21 (ISSN:13439502)

巻号頁・発行日

vol.17, no.4, pp.67-70, 2013-04

著者

中村 誠宏 森川 敏生 加藤 泰世 李 寧 長友 暁史 池 桂花 大串 輝樹 浅尾 恭伸 松田 久司 吉川 雅之

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.48, pp.535-540, 2006-09-15

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During the course of our characterization studies on bioactive saponins, the saponin fraction from the flowers, seeds of Camellia sinensis and C. japonica were found to show biological activities (gastroprotective, inhibitory effect on serum triglyceride (TG) elevation, and platelet aggregating effects, and so on). Therefore, we tried to isolate various bioactive saponin constituents from Camellia sinensis and C. japonica. 1. Camellia sinensis We have isolated nine new compounds [floratheasaponins A-I] from the flowers, twenty-three new compounds [theasaponins A_1-A_5, C_1, E_3-E_<13>, F_1-F_3, G_1, G_2 and H_1] from the seeds, and six new compounds [foliatheasaponins I-VI] from the leaves of C. sinensis. Floratheasaponins from the flowers were found to inhibit serum TG elevation in olive oilloaded mice. Theasaponins A_2 and E_2 showed inhibitory effects on ethanol-induced gastric mucosal lesions in rat, and their effects were stronger than that of reference compound, cetraxate hydrocholoride. 2. Camellia. Japonica We have isolated nine new compounds [camelliosides A-D, sanchasaponins A-D] from the flowers and six new compounds [camelliasaponins A_1, A_2, B_1, B_2, C_1, and C_2,] of C. japonica. Camelliosides, A and B showed gastroprotective and platelet aggregating effects. In addition, camelliasaponins B_1, B_2, C_1, and C_2 were found to exhibit inhibitory activity on ethanol absorption.