著者

岡田 洋平 川上 理 福田 博志 長浜 克志 斉藤 一隆 大塚 幸宏 木原 和徳 森田 隆 大島 博幸 江石 義信 菅野 純

出版者

泌尿器科紀要刊行会

雑誌

泌尿器科紀要 (ISSN:00181994)

巻号頁・発行日

vol.43, no.10, pp.739-742, 1997-10

被引用文献数

2

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3ヵ月前に無症候性肉眼的血尿に気づいた50歳男で,膀胱左壁の非乳頭状広基性腫瘍を認め,臨床病期はT3N0M0であった.生検材料の病理診断は小細胞癌であった.最初に行ったシスプラチン-アドリアマイシンの動注術前化学療法は無効であり,根治的膀胱摘除を行った.腫瘍組織は明らかに均質で,管状ないし索状に配列した小細胞より成り,pT3bR1L2V0N0であった.電子顕微鏡上,神経分泌顆粒を持つ小細胞癌と確認された.術後,シスプラチン,エトポシド,及びイホスファミドより成るアジュバント化学療法を4クール行った.術後26ヵ月に腫瘍再発の証拠なしに生存しているA 50-year-old man presented with asymptomatic gross hematuria which he had first noticed 3 months earlier. Clinical examinations revealed a non-papillary, broad-based tumor on the left lateral wall of the urinary bladder with a clinical stage of T3N0M0. The pathological diagnosis of a transurethral biopsy tissue specimen was small cell carcinoma. Neoadjuvant intraarterial infusion chemotherapy using cisplatin and adriamycin was initially administered but proved to be ineffective. Thus, we performed a radical cystectomy. The tumor tissue was apparently homogenous and composed of small cells arranged in sheets and solid patterns, and was staged to be pT3bR1L2V0N0. An electron microscopic study confirmed small cell carcinoma with neurosecretory granules. Postoperatively, 4 courses of adjuvant chemotherapy consisting of cisplatin, etoposide and ifosfamide were administered. The patient is alive without any evidence of tumor recurrence 26 months after the operation.

著者

長浜 克志 山田 拓己 一柳 暢孝 酒井 康之 鎌田 成芳 福田 博志 谷沢 晶子 渡辺 徹 斉藤 博 堀内 晋 町田 竜也

出版者

泌尿器科紀要刊行会

雑誌

泌尿器科紀要 (ISSN:00181994)

巻号頁・発行日

vol.48, no.1, pp.1-6, 2002-01

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Hautmann型膀胱再建術中,癌死・他因死・追跡不能を除く20例(男16例・女4例,29~73歳)を対象に,術後の回腸新膀胱の蓄尿・排尿状態を尿流動態検査(UDS)とアンケート調査により解析した.排尿回数は夜間に2回以上起床し排尿している例が19例中8例と高率であった.また,尿失禁は19例中昼間2例,就寝後12例にみられたが昼間は尿パッド平均2枚,夜間は1枚で対処可能であった.排尿時間は18例中9例が1分以内に排尿を終えたが3例では3分以上を要した.排尿状態については18例中満足8例,不満3例であった.USDを施行できたのは11例で観察期間は平均34.2±21.9ヵ月であった.残尿量は27.8±28.2ml,新膀胱最大容量は395.2±96.8mlで膀胱内圧は充分に低値であった.排尿時,外尿道括約筋筋電図で明らかな電位増強を11例中10例と高率に認めたWe analyzed the functional and urodynamic characteristics in 19 patients with ileal neobladder by the Hautmann procedure. A questionnaire survey by mail was performed for functional information of neobladder. Seventeen of the 19 patients (89.5%) could voluntarily void via the urethra and the others needed clean intermittent self catheterization (CIC) because of their significant residual volume. Eight of the 19 patients (42.1%) micturated at least two times at night. Two of the 19 patients (10.5%) were incontinent in the day time and 12 (63.2%) in the night time. They needed 2 pads in the day time and one pad at night on average. Eight out of 18 patients (44.4%) were satisfied with their micturition state. A urodynamic study showed the neobladder to be a low-pressure reservoir with a mean capacity of 395.2 +/- 96.8 ml. The mean residual volume of the patients without CIC was 27.8 +/- 28.2 ml. In 10 out of 11 patients high frequency and high amplitude spikes were seen by the perineal electromyogram in the voiding phase.