著者

千葉 智子 小川 隆志 阪田 久美子 宮崎 正三

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.19, no.2, pp.85-94, 2000-08-01 (Released:2010-06-08)

参考文献数

24

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As drug information service (DI) in a dental hospital, we evaluated the efficacy and safety of three products of the drug delivery system (DDS) (Periocline®, Elyzole®, Perio Chip®) for treatment of periodontitis, using literature of clinical trials.Nine literature references (4 for Periocline®, 4 for Elyzole®, 1 for Perio Chip®) were obtained from a MEDLINE database search on the Internet.The clinical trial design of each reference was a randomized control trial, and three were double blind randomized control trials. The treatment period and examination period were different for each reference. Items of clinical examination included pocket depth (PD), bleeding on probing (BOP), attachment level (AL), plaque index (PI) ; of these, PD was used in all trials.As for the efficacy of products evaluated by improvement of PD, two references for Periocline®, and one for Periochnp®, showed statistically significant improvement, but two references for Elyzole®, indicated superior improvement of PD in the control group rather than the test group. Only five of the references discussed side effects, but they were mild, transit, local effects.