著者

加來 洋子 枝並 宏治 福本 雅文 山口 雅巳 渋谷 鉱

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.2, pp.116-124, 2008-08-01 (Released:2010-06-08)

参考文献数

27

---

We conducted a study of judicial decisions on medical accidents covered between 1994 and 2000 by the Japanese press and Hanrei Times, a Japanese magazine specializing in judicial precedents, to obtain information on drug package inserts, and the extent to which these inserts are used as criteria for the judicial decisions.During the period studied, judicial decisions were issued regarding 514 cases of medical accidents, and a total of 1, 238 articles covering the decisions were published in the media referred to above. Looking at the changes in the number of cases by year, there were between 51 and 81 cases yearly from 1994 through 1999, while this number significantly increased in 2000, to 121.Out of the 514 cases, 34 (6.6%) were associated with drugs; drug package inserts were used as criteria for the decisions in four of the 34 cases, and 19 articles covering these four cases were carried in the media. Meanwhile, in 374 of the 514 cases (72.8%), it was judged that medical care personnel were to blame for the accidents, and these cases were covered in 1, 010 of the 1, 238 articles (81.6%) in the media.Common cases of malpractice pointed out to doctors and other medical personnel included violation of due care in terms of drug package inserts. Furthermore, a link between medical practice and the level of medical care was also indicated, as well as a link between package inserts and the level of medical care. The level of medical care varies due both to differences in medical services and the individual circumstances surrounding medical care providers, and negligence in collecting the latest information for medical findings is also included among the various types of malpractice.Other cases of malpractice included violations of accountability, in which medical care personnel neglected to inform patients of items mentioned in drug package inserts.Doctors, dentists, and other medical personnel must fully understand the descriptious given in drug package inserts.

著者

木村 陽介 山本 共夫 草塩 英治 前田 伸子

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.1, pp.9-14, 2017 (Released:2017-04-20)

参考文献数

18

---

Changes in the amount and physical properties of dental plaques were investigated in the oral cavity in which the oral fungal population was maintained at a low level by the long-term use of an antifungal agent as a mouthwash. For the antifungal agent used as a mouthwash, amphotericin B (AMPH-B), which specifically acts on fungi without influencing bacteria and is unlikely to be absorbed from the oral cavity or gastrointestinal mucosa, was selected. For the index of the fungal level in the oral cavity, Candida indigenous to the oral cavity was selected. We paid attention to time-course changes in the Candida count and the amount of dental plaques and its physical properties observed by palpation using a dental probe and macroscopically.The long-term use of the AMPH-B-containing mouthwash for 4 months or longer reduced the oral Candida count with time, confirming that the count can be maintained at a low level by continued use of the mouthwash. In addition, dental plaques macroscopically decreased as the Candida count decreased, and the physical properties the dental plaques also changed. Although the quantitative and qualitative influences of fungi in the oral cavity on dental plaques have not been investigated, it was clarified that long-term gargling with AMPH-B reduced the oral fungal level, which may have quantitatively and qualitatively changed dental plaques, i.e., microorganisms constituting the indigenous microbial flora in the oral cavity.Dental plaques show latent pathogenicity. In addition to the fact that causative microorganisms of the 2 major oral diseases, dental caries and periodontal disease, are present in dental plaques, the causative microorganisms of aspiration pneumonia, which is a major issue in the elderly, are also present. Thus, reduction of the amount of dental plaques may be beneficial for the health of the oral cavity as well as the whole body.

著者

小野 眞紀子 大野 奈穂子 長谷川 一弘 田中 茂男 小宮 正道 松本 裕子 藤井 彰 秋元 芳明

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.2, pp.79-85, 2008-08-01 (Released:2010-06-08)

参考文献数

34

被引用文献数

4

---

15種類のカルシウム拮抗薬による歯肉増殖症発生頻度を検討した.歯肉増殖症はamlodipine, diltiazem, manidipine, nicardipine, nifedipineおよびnisoldipine服用者に認められたが, azelnipine, barnidipine, benidipine, efonidipine, felodipine, flunarizine, nilvadipine, nitrendipineおよびverapamil服用者にはみられなった.最も高い発生頻度はnifedipine (7.6%) であり, diltiazem (4.1%) , manidipine (1.8%) , amlodipine (1.1%) , nisoldipine (1.1%) , nicardipine (0.5%) の順であった.Nifedipineによる歯肉増殖症発生頻度は, amlodipine, manidipine, nicardipine, nisoldipineの発生頻度と比較して有意に高かった.

著者

荻原 和孝 小川 智久 浅木 信安 沼部 幸博 鴨井 久一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.15, no.3, pp.130-136, 1996-12-01 (Released:2010-06-08)

参考文献数

19

---

Aqua oxidized water (AOW) and Aqua alkalic water (AAW) are made by acidic electrolyzed water making equipment; OXILIZER (OXILIZER Co., Tokyo, Japan) . AOW is acidic water with a pH under 2.7 and is processed by electrolysis through a small NaCl mediated specific membrane. It was over 1, 100mV of oxidation-reduction potential and includes Cl2, OH⋅, O3, ClO. AAW is alkalic water with pH 11.AOW has a strong bactericidal effect on bacteria and virus but the effect is reduced by the large number of organisms. It has a metallic corrosive function as well as an organic matter action. There are few reports about AAW sterilizing without a metallic corrosive action. The bactericidal effect of AAW to periodontopathic bacteria [Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn) ] and Staphylococcus aureus (Sa) and Escherichia coli (Ec) was investigated. The bactericidal effect of AOW and AAW were compared.Bacterial strain Sa : 209-P, Ec : B, Aa : Y4 and ATCC 29522, Pg : 381 and ATCC 33277, Pi : 25611, Fn : 25586 were grown at 3TC in BHI (aerobic and anaerobic condition), GAM contained hemin, menadion and yeast (anaerobic condition), and GAM broth (anaerobic condition), respectively. After washing by centrifugation, each bacteria was suspended in PBS.Serum and saliva were obtained from one healthy volunteer.Bactericidal activity was measured by colony count seeding and grown on BHI or Anaero columbia blood agar or GAM medium after treatment with AAW or AOW.The results were as follows:1. Bactericidal effect and effective concentration of AAWAa, Pg, Pi were killed in one minute (Aa; 108 to 104 CFU/ml, Pg; 108 to 103 CFU/ml, Pi ; less than 108 to 103 CFU/ml) from original 100% AAW, while it took more than one minute to kill Fn, and Sa and Ec had survived after ten minutes. Further, sterilizing activity decreased with AAW' s dilution. AOW shows that a 25% concentration is most effective against periodontopathic bacteria.2. The effect of saliva and serum on bactericidal activity of AAWAs for Aa, Pg and Pi, the addition of saliva or serum in a concentration of 1% of AAW had decreased bactericidal activity slightly. However, the bactericidal activity was completely negated by the addition of 10% serum of AAW. As for Fn, the bactericidal activity was negated in 1% of serumor salivery addition.

著者

渡邉 京子 東 泰孝 白数 慎也 大東 道治 大浦 清

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.3, pp.105-110, 2003-12-01 (Released:2010-06-08)

参考文献数

35

---

マクロファージは感染制御に必要不可欠であり, 自然免疫機構において重要な役割を担っている.感染が惹起されるとlipopolysaccharide (LPS) がマクロファージを刺激し, 炎症性サイトカインが産生される.一方, adenosineおよびATPは免疫刺激によっても細胞外へと放出された後, 様々な免疫機能を調節することが知られている.そこでわれわれは炎症やTh1/Th2バランスに関与するサイトカイン産生に対するadenosineおよびATPの免疫学的影響を検討した.AdenosineおよびATPはそれぞれマクロファージによるIL-10産生能を増強させたが, IL-1βおよびIL-12の産生能には影響を与えなかった.さらに, adenosineおよびATPはLPSで刺激したマクロファージによるIL.1βおよびIL-12に産生能を抑制した.これに対して, adenosineはLPSで刺激したマクロファージによるIL-10産生能を抑制したが, ATPは同IL-10産生能を増強した.以上の結果より, adenosineおよびATPが増加するような条件下においては, Th1やTh2免疫応答を含む広範囲な免疫反応に, なんらかの重要な役割を担っている可能性が示唆される.

著者

王 宝禮

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.1, pp.37-40, 2017 (Released:2017-04-20)

参考文献数

24

著者

山近 重生

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.1, pp.33-36, 2017 (Released:2017-04-20)

参考文献数

36

著者

川越 弘就 吉位 尚 大塚 芳基 竹野々 巌 寺延 治 古森 孝英

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.3, pp.139-143, 1999-12-01 (Released:2010-06-08)

参考文献数

22

---

Death due to gas gangrene following tooth extraction of mandibular third molar was reported. The patient was a 53-year-old female. Her mandibular left third molar was extracted 8 days before she was referred to our clinic. She did not receive any prophylactic antibiotics. After tooth extraction she developed swelling and pain of the left oral floor and the neck with severe sore throat and trismus. She had been treated with intravenous antibiotics and surgical drainage at a local hospital, however, the symptoms did not improve. The CT findings of the neck were abundant gas in the soft tissue of the neck. The diagnosis was cervical gas gangrene. The hematological tests revealed increase of white blood cells (13600/mm3), CRP (25.9mg/dl), blood sugar (332mg/dl), hypoalbuminemia (Alb ; 2.5g/dl), and liver dysfunction (GOT ; 42IU/l, GPT ; 63IU/l) .She seemed to be getting better due to drainage on Day 4 after admission, however, the neck skin became necrotic widely. On Day 8, rapid swelling and severe pain from the neck to chest were observed. The general conditions began to worsen, and she died of multi-organ failure on Day 12 (19 days after tooth extraction) . Enterococcus faecalis, Streptococcus milleri, Gemella haemolysan and Peptostreptococcus micros were isolated from the pus.It was considered that the necrotic tissues of the neck, which might cause residual infection, should have been removed completely, and the management for hyperglycemia and hypoalbuminemia was also very important to treat severe infectious gas gangrene.

著者

土屋 博紀 加藤 博詞 林 英明

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.17, no.3, pp.138-146, 1998-12-01 (Released:2010-06-08)

参考文献数

26

---

Green tea catechins have been widely used as an anticariogenic or antiplaque additive to mouthrinses, toothpastes, etc. Since their retention in the oral cavity is the determinant for thecaries preventive effects, the oral pharmacokinetic study was performed by assessing salivary concentrations of catechins with time after oral application using high-performance liquid chromatography with diode array detection. The optimized method enabled to simultaneously quantify eight catechins in the concentration range of 0.05-25.0μg/ml in saliva and mouthrinses with high resolution, recovery, and precision. Mouthrinsing experiments with the aqueous solutions of green tea extract (5.0mg/ml) revealed that each catechin maintained the salivary concentration at μg/ml levels for 1-60 min after mouthrinsing, especially (-) -epigal-locatechin gallate and (-) -gallocatechin gallate showed concentrations over 10μg/ml even after 60 min. When using the commercially available mouthrinses containing green tea extract, catechins were found in saliva up to 60 min after mouthrinsing, although their salivary concentrations were much lower. The retentive degree of catechins depended on their concentrations in mouthrinses and the number of times of mouthrinsing. Mouthrinsing with the green tea extract solution under optimal conditions would retain catechins in the oral cavity at least for 60 min after oral application, maintaining their salivary concentrations to show the potential caries preventive effects.

著者

渋川 直也 五味 一博 飯野 史明 金指 幹元 鈴木 丈一郎 大島 朋子 前田 伸子 新井 高

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.2, pp.83-90, 2003-08-01 (Released:2010-06-08)

参考文献数

39

被引用文献数

3

---

Azithromycin is an azalide antibiotic, which has a strong effect on a wide variety of oral bacteria. It is taken up by phagocytes and is released over a long period in the inflamed tissue. This study investigated the clinical and microbiological effects, and measured the drug concentration in gingival of periodontal patients systemically administered azithromycin. The subjects were 26 adults diagnosed with periodontitis and given azithromycin (zithromac®) 500 mg once daily for 3 days. Clinical parameters such as PD, GI, BOP and GCF were examined at days 0, 7, and 14, and subgingival plaque was collected by paper points at days 0, 4, 7 and 14. The total number of cultivable bacteria was counted and six of the periodontopathic bacteria —Porphyromonas gingivalis, Actinobacillus actinomysetemcomitans, Bacteroides forsythus, Prevotella intermedia, Prevotella nigresence, and Toreponema denticola—were assessed by the PCR method. The lining gingiva of periodontal pocket was collected by pocket curettage at days 4 and 7. The azithromycin concentration was measured by agar diffusion bioassay.The total number of bacteria was significantly decreased at days 4 and 7, but was slightly increased at day 14. Continuous reduction of the six bacteria was recognized until day 14 by PCR. These bacteria were not detected at day 14 without Porphyromonas gingivalis. This result might be due to improvement of anaerobic condition caused by pocket reduction. The azithromycin concentration in the lining gingival tissues of periodontal pocket was 2.92±1.97μg/g at day 4 and 1.27±0.95μg/g at day 7. Half the drug concentration was still detected at 7 days after the first administration in inflamed gingiva.These results indicate that azithromycin may be a useful adjunct agent for adult periodontitis. In the future, we will consider a new periodontal therapy using this behavior of azithromycin.

著者

森 紀美江 大野 康亮 山本 麗子 根本 敏行 道 健一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.11, no.3, pp.180-183, 1992-12-01 (Released:2010-06-08)

参考文献数

13

---

This has been a report of headache as side effects after administration of antimicrobial agent. We encountered two cases. Case 1 was diagnosed as having chronic mandibular osteomyelitis. Cefteram pivoxil (CFTM-PI) was administrated to this patient in three 200 mg doses daily, one dose after each meal. The patient complained of a headache 2 to 3 hours after receiving the initial dose of 200mg.Case 2 was diagnosed as possibly having postoperative infection. Roxithromycin (RU28965) was given in two 150 mg doses daily after breakfast and dinner for 4 days. This patient complained of a headache after the initial dose of 150mg, and it lasted for 4 days.In these two cases, appearance of the headache occurred at about the time of maximum serum level.We report these cases, because there have been few reports of headache as a side effect of these antibiotics.

著者

TAKEYA YAMADA KAZUHISA BESSHO KENICHIRO MURAKAMI SHINSUKE HORI TADAHIKO IIZUKA NATSUKI SEGAMI

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

ORAL THERAPEUTICS AND PHARMACOLOGY (ISSN:02881012)

巻号頁・発行日

vol.17, no.1, pp.18-22, 1998-04-01 (Released:2010-06-08)

参考文献数

20

被引用文献数

3

---

This study was conducted to asses the clinial efficacy of Sai-boku-to (Kanpo) in comparison to minor tranquilizer with vitamin B complex medication for the treatment of glossodynia.Either Sai-boku-to (7.5g per day) of minor tranquilizer (Diazepam) 6mg per day with vitamine B complex medication for three months was P. O. administered to 104 cases. The clinical examination was carried out in order to evaluate the subjective symptoms such as pain, heat sensation, and unpleasent feeling in comcomitant treatment of glossodynia.After three-month administration the success rates were 75.8 %, 87.1 %, and 88.7 % in the Sai-boku-to medication group and 73.8 %, 71.4 %, 69.0 % in the minor tranquilizer medication group. The Sai-boku-to medication group was significantry superior to the minor tranquilizer medication group. The side effect of the sleepiness was found in 13 cases in the minor tranquilizer medication group. On the contrary, a mild signs and symptoms of digestive discomfort was noted in three cases in the Sai-boku-to medication group.These results suggested that Sai-boku-to was a clinically useful drug for the treatment of glossodvnia.

著者

千葉 智子 小川 隆志 阪田 久美子 宮崎 正三

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.19, no.2, pp.85-94, 2000-08-01 (Released:2010-06-08)

参考文献数

24

---

As drug information service (DI) in a dental hospital, we evaluated the efficacy and safety of three products of the drug delivery system (DDS) (Periocline®, Elyzole®, Perio Chip®) for treatment of periodontitis, using literature of clinical trials.Nine literature references (4 for Periocline®, 4 for Elyzole®, 1 for Perio Chip®) were obtained from a MEDLINE database search on the Internet.The clinical trial design of each reference was a randomized control trial, and three were double blind randomized control trials. The treatment period and examination period were different for each reference. Items of clinical examination included pocket depth (PD), bleeding on probing (BOP), attachment level (AL), plaque index (PI) ; of these, PD was used in all trials.As for the efficacy of products evaluated by improvement of PD, two references for Periocline®, and one for Periochnp®, showed statistically significant improvement, but two references for Elyzole®, indicated superior improvement of PD in the control group rather than the test group. Only five of the references discussed side effects, but they were mild, transit, local effects.

著者

松野 智宣 北原 和樹 田中 正司 佐藤 田鶴子 荒井 千明

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.21, no.2, pp.53-58, 2002-08-01 (Released:2010-06-08)

参考文献数

13

被引用文献数

2

---

Platelet-rich plasma (PRP), separated by centrifugation of autologous blood, is a plasma containing numerous platelets. Consequently, efficient separation of PRP can provide highly concentrated autologous growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), and insulin-like growth factor-I (IGF-I), derived from α granules. However, it requires a substance to trigger platelet aggregation, in order to activate platelets to release the growth factors.In the present study, we investigated a procedure of activating platelets (aggregation) with calcium chloride alone, in the absence of thrombin, the safety of which is suspected. Prior to the investigation, we sought the optimal centrifugal conditions, i.e., centrifugal gravity and time, for separation of PRP. As a result, we discovered that a centrifugal gravity of 130 (×g) and a centrifugal time of 10 min, are the optimal conditions for separating PRP. The time required for platelet aggregation was prolonged in platelet activation by calcium chloride alone, as compared with platelet activation by thrombin. However, activation of platelets with calcium chloride alone demonstrated gelatinization of PRP indicative of sufficient fibrin formation.

著者

土屋 博紀 加藤 博詞

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.17, no.3, pp.147-154, 1998-12-01 (Released:2010-06-08)

参考文献数

30

被引用文献数

1

---

Green tea catechins with the anticariogenic activity have been recently revealed to maintain their salivary concentrations after mouthrinsing. The mechanism underlying such retention in the oral cavity was studied by quantitatively evaluating the adsorption of catechins after vortex-mixing with hydroxyapatite, buccal mucosal cells, and proteins in artificial saliva. Treatment with hydroxyapatite decreased catechins in supernatants and such a decrease was more significant by coating hydroxyapatite with saliva as an experimental pellicle. When treating with mucosal cells, unwashed cells decreased catechins in ultrafiltrates more significantly than washed cells. Catechins in ultrafiltrates were decreased by treating with albumin and mucin depending on protein concentrations. These reduced concentrations in supernatants and ultrafiltrates meant the adsorption of catechins to hydroxyapatite, mucosal cells, and proteins. In structural comparison, four gallate esters were superior in the adsorptive activity to the corresponding non-esters. Concentration changes of salivary ctechins after mouthrinsing with green tea extracts showed that the retention of catechins in the oral cavity was associated with their adsorption. The present results suggested that green tea catechins are adsorbed by the teeth, pellicles and oral mucosa, and that salivary proteins such as albumin and mucin are responsible for the adsorption. The adsorbed catechins are considered to gradually be released to maintain the salivary concentrations after oral application.

著者

寺門 永顕 新谷 悟 原 慎吾 篠原 裕志 矢野 淳也 栢原 浩彰 中城 公一 日野 聡史 浜川 裕之

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.2, pp.76-82, 2003-08-01 (Released:2010-06-08)

参考文献数

8

---

The efficacy of azithromycin as a chemoprophylactic agent for acute dental infection was assessed, and a questionnaire survey about the impression of azithromycin was conducted. METHODS: Eighty-three patients were given 500 mg of azithromycin for three days. Seven days after the onset of the treatment, we evaluated the clinical symptoms and collected the questionnaires. RESULTS: Clinical efficacy was observed in 89.2% of the patients, and that by questionnaire was 86.7%. Diarrhea as a side effect was seen in two patients. In the questionnaire, 79% of patients noted its effect from the second to fourth day after the medication. Although half of the patients did not care about the convenience, of taking the medication once a day, which is one of the advantages of azithromycin, most of the patients were satisfied with its efficacy.Furthermore, 72.3% of patients considered azithromycin to be significantly more acceptable compared with other antibiotics. CONCLUSION : Azithromycin is a useful therapeutic regimen for the treatment of acute dental infections.

著者

服部 孝範 古賀 賢三郎 可知 久志 後藤 学 田中 悟 成田 秀貴 生川 哲也 河合 幹

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.6-8, 1982-12-31 (Released:2010-06-08)

参考文献数

3

---

Agar well method was compared with cup method. Diameter of inhibition zone of Agar well method was smaller than diameter of inhibition zone of cup method.Diameter of inhibition zone of Agar well method was almost same size and the measured value of Agar well method was low in aberration.

著者

久野 吉雄

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.125-144, 1982-12-31 (Released:2010-06-08)

著者

道 健一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.145-155, 1982-12-31 (Released:2010-06-08)

被引用文献数

1

著者

牛山 美奈 池田 龍二 新田 哲也 田實 裕介 宮脇 昭彦 山口 辰哉 下堂薗 権洋 牛之濱 風見 松井 竜太郎 杉原 一正 中村 典史 山田 勝士

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.3, pp.143-150, 2008-12-01 (Released:2010-06-08)

参考文献数

14

---

In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.