著者

千葉 智子 小川 隆志 阪田 久美子 宮崎 正三

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.19, no.2, pp.85-94, 2000-08-01 (Released:2010-06-08)

参考文献数

24

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As drug information service (DI) in a dental hospital, we evaluated the efficacy and safety of three products of the drug delivery system (DDS) (Periocline®, Elyzole®, Perio Chip®) for treatment of periodontitis, using literature of clinical trials.Nine literature references (4 for Periocline®, 4 for Elyzole®, 1 for Perio Chip®) were obtained from a MEDLINE database search on the Internet.The clinical trial design of each reference was a randomized control trial, and three were double blind randomized control trials. The treatment period and examination period were different for each reference. Items of clinical examination included pocket depth (PD), bleeding on probing (BOP), attachment level (AL), plaque index (PI) ; of these, PD was used in all trials.As for the efficacy of products evaluated by improvement of PD, two references for Periocline®, and one for Periochnp®, showed statistically significant improvement, but two references for Elyzole®, indicated superior improvement of PD in the control group rather than the test group. Only five of the references discussed side effects, but they were mild, transit, local effects.

著者

宮崎 正三

出版者

北海道大学

巻号頁・発行日

1974

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博士論文

著者

宮崎 正三 堀 了平 有田 隆一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.95, no.6, pp.629-633, 1975-06-25 (Released:2008-05-30)

参考文献数

14

被引用文献数

2 6

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Four different solid phases of tetracycline (trihydrate, anhydrate, dehydrate, and amorphous) were isolated. These phases were characterized by using IR spectroscopy, X-ray powder diffraction, and thermogravimetric and differential thermal analyses. Dissolution behavior of these phases in distilled water was investigated and an appreciable difference in the dissolution behavior was detected between the amorphous and the other solid phases. The effect of the solid phases on bioavailability of tetracycline was also studied. Blood plasma levels obtained in rabbits and blood levels in rats after intraduodenal administration of the trihydrate and amorphous were compared, and its results indicated that the solubility difference between the two phases has an effect on the bioavailability of tetracycline. The cumulative excretion of tetracyc1ine in urine after oral administration of the two phases to human subjects was also examined and its results indicated that the cumulative amount after administration of the amorphous was slightly higher than that of the trihydrate.

著者

宮崎 正三 有田 隆一 堀 了平 伊藤 圭二

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.22, no.3, pp.638-642, 1974-03-25 (Released:2008-03-31)

被引用文献数

13 21

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The existence of the two crystalline forms of chlortetracycline hydrochloride (CTC-HCI) was confirmed by infrared spectroscopy and X-ray diffraction. From the dissolution studies with crystalline powder and compressed disk, an appreciable difference in the dissolution behavior in water was detected between the two forms. In order to determine the effect of polymorphism on the gastrointestinal absorption of CTC-HCl, blood plasma levels obtained in rabbits after intraduodenal administration and cumulative amounts excreted in human subjects after oral administration of the two forms were compared. The results indicated that polymorphic state of CTC-HCl significantly influences bioavailability of the CTC-HCl.