著者

岩本 奈織子 鈴木 瑞佳 高木 康伸 堀口 慎一郎 有賀 智之

出版者

一般社団法人 日本遺伝性腫瘍学会

雑誌

遺伝性腫瘍 (ISSN:24356808)

巻号頁・発行日

vol.23, no.3, pp.114-118, 2023-12-15 (Released:2023-12-15)

参考文献数

22

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BRCA1/2遺伝学的検査は,PARP(Poly ADP-ribose polymerase)阻害薬のコンパニオン診断から遺伝性乳癌卵巣癌(hereditary breast and ovarian cancer;HBOC)の診断まで広く晋及しつつある.今後,BRCA1/2遺伝学的検査数の増加と,それに伴いBRCA1/2病的バリアント保持者の増加が見込まれる.BRCA1/2病的バリアント保持者では,年に1回の乳房造影MRI検査でのサーベイランスが推奨されている.MRIでのみ描出される病変に対しては,MRIガイド下生検(MRI-guided vaccuum-assist biopsy;MRI-VAB)が必要となるため,MRIを行う際にはMRI-VABが可能な施設との連携が望ましいとされている.しかしながら,実際に保険診療でMRI-VABを行っている施設は少ない.当院では2022年6月からMRI-VABを開始し,2023年5月までの期間においてMRI-VABを6例に施行した.患者の年齢は30~60代であり,半数は悪性であった.1例は,BRCA2病的バリアント保持者で非浸潤性乳管癌(ductal carcinoma in situ;DCIS)と診断されたHBOC症例であった.今回,われわれはMRI-VABの導入時に必要であった準備と過程を報告する.

著者

溜渕 功史 山田 安之 石垣 祐三 高木 康伸 中村 雅基 前田 憲二 岡田 正実

出版者

SEISMOLOGICAL SOCIETY OF JAPAN

雑誌

地震 第1輯 (ISSN:00371114)

巻号頁・発行日

vol.62, no.4, pp.193-207, 2010

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We found eight <I>M</I> 5.1 characteristic earthquakes regularly occurring since 1966 on the plate boundary between the Eurasian plate and the Philippine Sea plate near Miyakojima Island, the Ryukyu Arc, Japan. The quake recurrence interval was 5.89 years in average, and the standard deviation was only 0.73 years. The accumulating stress presumably ruptured the same asperity enclosed by the creeping zone repeatedly. Also, we found three other groups of small repeating earthquakes of <I>M</I> 4, which occurred close to the hypocenters of the <I>M</I> 5 events. Those groups also occurred regularly and we can consider them to be 'characteristic' earthquake sequences. Now, we called those groups A, B, and C. It is not clear whether groups A and B had an intrinsic recurrence interval or if they influenced each other. However, two events of group C occurred within one week after the <I>M</I> 5 quakes, indicating that the <I>M</I> 5 events triggered the group C events whose asperity had suffcient strain energy. No earthquake exceeding <I>M</I> 7, which could change the recurrence intervals, has been observed on the subduction zone around the Ryukyu Islands. Therefore, there should be numerous characteristic earthquake sequences in other areas of the Ryukyu district. We expect that the next <I>M</I> 5 earthquake at 50 km depth on the plate boundary near Miyakojima Island will occur between September 2012 and July 2014 with 70% probability, using the small-sample theory with a log-normal distribution model. Moreover, the <I>M</I> 5 event may be accompanied by an <I>M</I> 4 quake that could rupture the asperity of group C within one week.

著者

溜渕 功史 山田 安之 石垣 祐三 高木 康伸 中村 雅基 前田 憲二 岡田 正実

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.62, no.4, pp.193-207, 2010-03-15 (Released:2012-03-26)

参考文献数

26

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We found eight M 5.1 characteristic earthquakes regularly occurring since 1966 on the plate boundary between the Eurasian plate and the Philippine Sea plate near Miyakojima Island, the Ryukyu Arc, Japan. The quake recurrence interval was 5.89 years in average, and the standard deviation was only 0.73 years. The accumulating stress presumably ruptured the same asperity enclosed by the creeping zone repeatedly. Also, we found three other groups of small repeating earthquakes of M 4, which occurred close to the hypocenters of the M 5 events. Those groups also occurred regularly and we can consider them to be ‘characteristic’ earthquake sequences. Now, we called those groups A, B, and C. It is not clear whether groups A and B had an intrinsic recurrence interval or if they influenced each other. However, two events of group C occurred within one week after the M 5 quakes, indicating that the M 5 events triggered the group C events whose asperity had suffcient strain energy. No earthquake exceeding M 7, which could change the recurrence intervals, has been observed on the subduction zone around the Ryukyu Islands. Therefore, there should be numerous characteristic earthquake sequences in other areas of the Ryukyu district. We expect that the next M 5 earthquake at 50 km depth on the plate boundary near Miyakojima Island will occur between September 2012 and July 2014 with 70% probability, using the small-sample theory with a log-normal distribution model. Moreover, the M 5 event may be accompanied by an M 4 quake that could rupture the asperity of group C within one week.