著者

石川 雄大 高木 昭佳 梶浦 新也 真鍋 優希子 髙橋 則正 小野 敦央 加藤 敦

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.1, pp.1-9, 2021-01-10 (Released:2022-01-10)

参考文献数

24

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Chemotherapy-induced peripheral neuropathy (CIPN) reduces patient quality of life, but there is little evidence of preexisting supportive care drugs. Mirogabalin is a novel drug with indications for peripheral neuropathic pain, and its mechanism of action involves strong and selective binding to the voltage-gated calcium channel α2δ subunit. We examined the effects of mirogabalin on CIPN. We followed up 21 patients with CIPN caused by taxanes or platinum-based anticancer drugs who started mirogabalin. A numerical rating scale (NRS) was used for the evaluation, and pharmacists evaluated the mirogabalin dose at its initiation by creatinine clearance in all patients, and no overdoses occurred. Mirogabalin significantly reduced NRS scores from a median of 6 to 2 (P < 0.001), and the median number of days of mirogabalin administration until determination of the best effect was 29.5 days. Furthermore, the median NRS significantly decreased by administration of mirogabalin in both the taxanes-based anticancer drug group and the platinum-based anticancer drug group. In the safety investigation, a somnolence grade of 1 or 2 was observed in 4 patients, an edema grade of 1 or 2 in 4 patients, and an edema grade of 3 was observed in 1 patient. There were no serious side effects that required hospitalization. Our study suggests mirogabalin has a palliative effect on CIPN and may be an important supportive care drug for chemotherapy. Simultaneously, it’s considered that pharmacists evaluate renal function and contribute to proper use, so that patients can expect the maximum drug efficacy after the introduction of mirogabalin.

著者

高木 昭佳 吉田 直子 渡部 有貴 中川 洋子 北澤 英徳 三村 泰彦 足立 伊佐雄 川上 純一

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.1, pp.15-22, 2007-01-10

参考文献数

23

被引用文献数

1 3

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To improve the drug information service and standardize pharmaceutical care for inpatients of the Department of Japanese Oriental Medicine, Toyama University Hospital, we created a Kampo (Oriental) medicine database and used it in the preparation of medication instruction sheets. The database was configured on a Power Mac G4 (Apple Computer, Inc.; Cupertino, CA, USA) personal computer operating on Mac OS 10.4 using FileMaker Pro 6 database software. The database comprised 5 interlinked files-patient registration file, constituent crude drug registration file, Kampo formula registration file, and a file for the making and storing of instruction sheets. Information on 239 crude drugs and 560 Kampo formulae obtained from our "Hospital Manual for Japanese Oriental Medicine" was recorded in the database. Further, color photographs of the plants from which the herbal medicines were derived and other natural medicines were included in the instruction sheets to give patients a better understanding of Kampo pharmacotherapy. The database has made it easy to prepare personalized instruction sheets, which can be done by only entering the patient's ID and the Kampo formulae prescribed or crude drug name. In addition, the medication instructions for each inpatient and the indication(s) of prescribed Kampo formulae have been recorded in the database for later use in the management of inpatient histories and to provide utilization statistics for Kampo medicines. When a questionnaire survey of inpatients of the Department of Japanese Oriental Medicine was carried out to evaluate the usefulness of the medication instruction sheets prepared using the database, it was found that they gave patients a better understanding of Kampo pharmacotherapy and made them more interested in it. In conclusion, our database system will help improve the drug information service and quality of pharmaceutical care for inpatients treated with Kampo formulae prepared from crude drugs.