著者

石川 雄大 高木 昭佳 梶浦 新也 真鍋 優希子 髙橋 則正 小野 敦央 加藤 敦

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.1, pp.1-9, 2021-01-10 (Released:2022-01-10)

参考文献数

24

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Chemotherapy-induced peripheral neuropathy (CIPN) reduces patient quality of life, but there is little evidence of preexisting supportive care drugs. Mirogabalin is a novel drug with indications for peripheral neuropathic pain, and its mechanism of action involves strong and selective binding to the voltage-gated calcium channel α2δ subunit. We examined the effects of mirogabalin on CIPN. We followed up 21 patients with CIPN caused by taxanes or platinum-based anticancer drugs who started mirogabalin. A numerical rating scale (NRS) was used for the evaluation, and pharmacists evaluated the mirogabalin dose at its initiation by creatinine clearance in all patients, and no overdoses occurred. Mirogabalin significantly reduced NRS scores from a median of 6 to 2 (P < 0.001), and the median number of days of mirogabalin administration until determination of the best effect was 29.5 days. Furthermore, the median NRS significantly decreased by administration of mirogabalin in both the taxanes-based anticancer drug group and the platinum-based anticancer drug group. In the safety investigation, a somnolence grade of 1 or 2 was observed in 4 patients, an edema grade of 1 or 2 in 4 patients, and an edema grade of 3 was observed in 1 patient. There were no serious side effects that required hospitalization. Our study suggests mirogabalin has a palliative effect on CIPN and may be an important supportive care drug for chemotherapy. Simultaneously, it’s considered that pharmacists evaluate renal function and contribute to proper use, so that patients can expect the maximum drug efficacy after the introduction of mirogabalin.

著者

石川 雄大

巻号頁・発行日

2013

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筑波大学修士 (情報学) 学位論文・平成25年3月25日授与 (30955号)

著者

家垣 典幸 宮本 嘉明 石川 雄大 日比 陽子 村松 慎一 鍋島 俊隆 新田 淳美

雑誌

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology (ISSN:13402544)

巻号頁・発行日

vol.32, no.2, pp.119-120, 2012-04-25

著者

石川 雄大 福本 准也 和田 友孝 大月 一弘 岡田 博美

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会ソサイエティ大会講演論文集

巻号頁・発行日

vol.2007, no.2, 2007-08-29

被引用文献数

1