- 著者
- Ken Kozuma Taishiro Chikamori Jun Hashimoto Junko Honye Takanori Ikeda Sugao Ishiwata Mamoru Kato Hiroshi Kondo Kosuke Matsubara Kazuma Matsumoto Naoya Matsumoto Sadako Motoyama Kotaro Obunai Hajime Sakamoto Kyoko Soejima Shigeru Suzuki Koichiro Abe Hideo Amano Hirofumi Hioki Takashi Iimori Hideki Kawai Hisanori Kosuge Tatsuya Nakama Yasuyuki Suzuki Kazuya Takeda Akiko Ueda Takashi Yamashita Kenzo Hirao Takeshi Kimura Ryozo Nagai Masato Nakamura Wataru Shimizu Nagara Tamaki on behalf of the Japanese Circulation Society Joint Working Group
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-21-0379, (Released:2022-04-22)
- 参考文献数
- 230
- 被引用文献数
- 7
- 著者
- Hideharu Hagiya Ryohei Kokado Akiko Ueda Hideo Okuno Daiichi Morii Shigeto Hamaguchi Norihisa Yamamoto Hisao Yoshida Kazunori Tomono
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.58, no.18, pp.2621-2625, 2019-09-15 (Released:2019-09-15)
- 参考文献数
- 10
- 被引用文献数
- 1 24
Objective The importance of antimicrobial stewardship is increasingly highlighted in this age of antimicrobial resistance. A better comprehension of adverse drug events (ADEs) can promote the appropriate use of antibiotics. We aimed to quantify the incidence of ADEs associated with broad-spectrum systemic antibiotics in a hospital setting. Methods We conducted a six-month prospective, observational study at Osaka University Hospital to describe the incidence of ADEs in patients hospitalized in general wards undergoing treatment with broad-spectrum antibiotics [carbapenems, piperacillin/tazobactam (PIPC/TAZ), and anti-methicillin-resistant Staphylococcus aureus agents]. The occurrence of ADE was defined as any cardiac, gastrointestinal, hepatobiliary, renal, neurologic, hematologic, dermatologic, or musculoskeletal manifestation after 48 hours or more of systemic antibiotic therapy. Results The 3 most frequently prescribed antibiotics were PIPC/TAZ (242 cases), meropenem (181 cases), and vancomycin (92 cases). Of 689 patients, 118 (17.1%) experienced ADEs, including gastrointestinal (6.4%), hepatobiliary (4.2%), dermatologic (2.5%), and renal (2.3%) manifestations. Patients treated with PIPC/TAZ, meropenem, doripenem, vancomycin, daptomycin, and teicoplanin developed ADEs at rates of 20.7%, 16.0%, 15.4%, 19.6%, 11.8%, and 10.9%, respectively. Conclusion Our study provides a quantitative value for the incidence of ADEs associated with broad-spectrum antibiotics in clinical practice. To optimize patient safety, clinicians need to be aware of the risks associated with antibiotic administration.
- 著者
- Hideharu Hagiya Ryohei Kokado Akiko Ueda Hideo Okuno Daiichi Morii Shigeto Hamaguchi Norihisa Yamamoto Hisao Yoshida Kazunori Tomono
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.2603-18, (Released:2019-05-22)
- 参考文献数
- 10
- 被引用文献数
- 24
Objective The importance of antimicrobial stewardship is increasingly highlighted in this age of antimicrobial resistance. A better comprehension of adverse drug events (ADEs) can promote the appropriate use of antibiotics. We aimed to quantify the incidence of ADEs associated with broad-spectrum systemic antibiotics in a hospital setting. Methods We conducted a six-month prospective, observational study at Osaka University Hospital to describe the incidence of ADEs in patients hospitalized in general wards undergoing treatment with broad-spectrum antibiotics (carbapenems, piperacillin/tazobactam [PIPC/TAZ], and anti-methicillin-resistant Staphylococcus aureus agents). The occurrence of ADE was defined as any cardiac, gastrointestinal, hepatobiliary, renal, neurologic, hematologic, dermatologic, or musculoskeletal manifestation after 48 hours or more of systemic antibiotic therapy. Results The 3 most frequently prescribed antibiotics were PIPC/TAZ (242 cases), meropenem (181 cases), and vancomycin (92 cases). Of 689 patients, 118 (17.1%) experienced ADEs, including gastrointestinal (6.4%), hepatobiliary (4.2%), dermatologic (2.5%), and renal (2.3%) manifestations. Patients treated with PIPC/TAZ, meropenem, doripenem, vancomycin, daptomycin, and teicoplanin developed ADEs at rates of 20.7%, 16.0%, 15.4%, 19.6%, 11.8%, and 10.9%, respectively. Conclusion Our study provides a quantitative value for the incidence of ADEs associated with broad-spectrum antibiotics in clinical practice. To optimize patient safety, clinicians need to be aware of the risks associated with antibiotic administration.
- 著者
- Kengo UEDA Akiko UEDA Kiyokazu OZAKI
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.81, no.2, pp.193-196, 2019 (Released:2019-02-09)
- 参考文献数
- 17
- 被引用文献数
- 4
A tumor had formed in the right eye of a 14-year-old male chinchilla. The black-and-white-colored tumor occupied the entire eye except for the lens and had invaded extensively inside the orbit. Histologically, round, spindle- to polygonal-shaped tumor cells had proliferated in a solid-sheet arrangement. The tumor cells exhibited polymorphic nuclei ranging from round- to polygonal-shaped, as well as abundant cytoplasm, which occasionally contained melanin granules. In some areas, several cells were surrounded by the basal lamina. Additionally, the tumor showed cervical lymph-node metastasis. Upon immunostaining, the tumor cells were positive for epithelial markers (cytokeratin AE1/AE3, 8/18, and 20), S100, and vimentin. Consequently, we diagnosed primary pleomorphic iridociliary adenocarcinoma with lymph-node metastasis. This is the first report of iridociliary adenocarcinoma in chinchillas.
- 著者
- Kengo UEDA Akiko UEDA Kiyokazu OZAKI
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.80, no.6, pp.973-976, 2018 (Released:2018-06-29)
- 参考文献数
- 18
- 被引用文献数
- 7
Despite being rarely reported, improved diagnostic and prognostic indicators are necessary for treating malignant melanoma in rabbits. In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-like proliferation of polymorphic cells, with anisocytosis and varying amount of melanin granules. Tumors had displaced almost 50% of the lung and liver tissue, and tumor metastasis was the cause of early death in both rabbits. Ki-67-positive population was high in both, and it was found to be useful in assessing the outcome and malignancy. In addition, Melan-A, HMB-45, PNL2 and S100 established a useful immunohistochemical panel for the diagnosis of melanocytic tumor in rabbits.