著者

Akiko WATANABE

出版者

Society of Advanced Science

雑誌

Journal of Advanced Science (ISSN:09155651)

巻号頁・発行日

vol.32, no.1, pp.32704, 2020 (Released:2020-09-25)

参考文献数

4

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KSP Inc. was established in 1986 as the core entity of the Kanagawa Science Park as a result of a project designed to realize the “Brain Center Framework” policy of Kanagawa Prefecture, and as the aim of Kawasaki City to become a mecca for science, technology, and research and development in Japan and Asia. KSP Inc. carries out the comprehensive management of the Kanagawa Science Park. Incubation managers of KSP assist the tenants of Kanagawa Science Park and other startups for business outside the park. In addition, KSP supports training of entrepreneurs and the commercialization of technical seeds by signing MOUs with various universities for concerning cooperation. Also we have “KSP Business Innovation School (KSP BIS)” for developing entrepreneurs for businesspersons for 28 years. More than 650 people graduated from the KSP BIS. The core concept of this school’s curriculum is the “How a business plan should be written?” One can experience real-time open innovations and join business networking in various industries, aiming at development of entrepreneurship.

著者

Jun Matsuura Ryo Inoue Tomohisa Takagi Sayori Wada Akiko Watanabe Takashi Koizumi Mao Mukai Ikuko Mizuta Yuji Naito Toshiki Mizuno

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.65, no.3, pp.240-244, 2019 (Released:2019-11-01)

参考文献数

18

被引用文献数

8

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a major hereditary small vessel disease caused by mutations in NOTCH3. The variations in progression and severity among patients suggest that the CADASIL phenotype is modified by some genetic and environmental factors. Recent studies have shown the potential roles of gut microbiota in human diseases. We hypothesized that gut microbiota modifies the disease phenotype. We performed gut microbial meta 16S rRNA analysis of fecal samples from 15 CADASIL patients and 16 controls. The microbial α- and β-diversities and taxonomy were compared between CADASIL patients and controls and between CADASIL patients with and without an ischemic stroke history. No significant difference in α- or β-diversity was observed in either case-control or subgroup comparisons. In the taxonomic microbial analysis, there was a significant increase in abundance of 6 genera and significant decrease in 2 genera in CADASIL patients compared with controls. There was a significant decrease in abundance of 2 genera in CADASIL patients with compared with those without stroke. This is the first study on CADASIL focusing on gut microbiota. Our findings suggest that gut microbiota modifies the onset and progression of CADASIL.

著者

Mikio Wada Hiromi Ueda Akiko Watanabe Natsuko Yuki Sadao Yamashita

出版者

日本プライマリ・ケア連合学会

雑誌

General Medicine (ISSN:13460072)

巻号頁・発行日

vol.15, no.1, pp.47-51, 2014-06-20 (Released:2014-06-27)

参考文献数

7

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A 31-year-old healthy mother of twins developed Guillain-Barré syndrome in her fourth gestational week of pregnancy. Impaired motor coordination, sensation, and joint position sense were observed. Immunoglobulin therapy was not performed given the early stage of pregnancy. She received rehabilitation to accommodate changes in her body shape and movements necessary for pregnancy, childbirth, and childcare. The patient delivered a healthy baby by cesarean section. By 42 weeks postpartum, she was capable of almost all housework activities and childcare. Family support was important in this case. Patient-oriented intervention, which included periodic confirmation and establishment of goals in each phase and continuity of intervention, was also essential.