- 著者
- Atsushi Hinenoya Sharda Prasad Awasthi Noritomo Yasuda Ayaka Shima Hirofumi Morino Tomoko Koizumi Toshiaki Fukuda Takanori Miura Takashi Shibata Shinji Yamasaki
- 出版者
- National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- vol.68, no.4, pp.276-279, 2015 (Released:2015-07-22)
- 参考文献数
- 16
- 被引用文献数
- 8 21
In this study, we evaluated and compared the antibacterial activity of chlorine dioxide (ClO2) and sodium hypochlorite (NaClO) on various multidrug-resistant strains in the presence of bovine serum albumin and sheep erythrocytes to mimic the blood contamination that frequently occurs in the clinical setting. The 3 most important species that cause nosocomial infections, i.e., methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa (MDRP), and multidrug-resistant Acinetobacter baumannii (MDRA), were evaluated, with three representative strains of each. At a 10-ppm concentration, ClO2 drastically reduced the number of bacteria of all MDRP and MDRA strains, and 2 out of 3 MRSA strains. However, 10 ppm of NaClO did not significantly kill any of the 9 strains tested in 60 seconds (s). In addition, 100 ppm of ClO2 completely killed all MRSA strains, whereas 100 ppm of NaClO failed to significantly lower the number of 2 MRSA strains and 1 MDRA strain. A time-course experiment demonstrated that, within 15 s, 100 ppm of ClO2, but not 100 ppm of NaClO, completely killed all tested strains. Taken together, these data suggest that ClO2 is more effective than NaClO against MRSA, MDRP, and MDRA, and 100 ppm is an effective concentration against these multidrug-resistant strains, which cause fatal nosocomial infections.
- 著者
- Koji SUGITA Ayaka SHIMA Kaho TAKAHASHI Yasuyoshi MATSUDA Masaki MIYAJIMA Marin HIROKAWA Hirotaka KONDO Junpei KIMURA Genki ISHIHARA Keitaro OHMORI
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.21-0063, (Released:2021-04-26)
- 被引用文献数
- 10
A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds.
- 著者
- Atsushi Hinenoya Sharda Prasad Awasthi Noritomo Yasuda Ayaka Shima Hirofumi Morino Tomoko Koizumi Toshiaki Fukuda Takanori Miura Takashi Shibata Shinji Yamasaki
- 出版者
- National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- pp.JJID.2014.294, (Released:2015-01-20)
- 参考文献数
- 16
- 被引用文献数
- 9 21
In this study, we evaluated the antibacterial activity of chlorine dioxide (ClO2) compared with sodium hypochlorite (NaClO) on various multidrug-resistant strains in the presence of bovine serum albumin and sheep erythrocytes to mimic the frequent blood contamination in clinical environment. The 3 most important species causing nosocomial infections, i.e., methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa (MDRP) and multidrug-resistant Acinetobacter baumannii (MDRA) were evaluated, with 3 representative strains from each. At a 10 ppm-concentration, ClO2 drastically reduced the number of all MDRP and MDRA, and 2 out of 3 MRSA strains, but NaClO was unable to cause any remarkable attenuation for any of the 9 strains tested in 60 seconds. Increased concentration of 100 ppm enabled ClO2 to completely kill MRSA strains, whereas NaClO failed to significantly lower the number of 2 MRSA and 1 MDRA strains. A time-course experiment demonstrated that, within 15 seconds, 100 ppm of ClO2 could kill completely all tested strains but NaClO at this concentration failed to do so. Together, these data suggest that ClO2 is more effective than NaClO against MRSA, MDRP and MDRA, and 100 ppm could be a practical concentration of ClO2 against these multidrug-resistant strains, which may cause fatal nosocomial infections.