- 著者
- Chiharu Aizawa Masahiro Okabe Daisuke Takahashi Makoto Sagasaki Mao Watanabe Toshinari Fujimoto Yuuki Yoshioka Ai Katsuma Ai Kimura Daisuke Miyamoto Nana Sato Ken Okamoto Kimiyoshi Ichida Yoichi Miyazaki Takashi Yokoo
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.0678-22, (Released:2023-02-08)
- 参考文献数
- 31
- 被引用文献数
- 1
Exercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes. We herein report a 16-year-old Japanese football player with familial RHUC with compound heterozygous mutations in urate transporter 1 (URAT1) who presented with recurrent EIAKI. As prophylaxis (hydration during exercise) could not prevent EIAKI, febuxostat was initiated. EIAKI was not observed for 16 months despite exercising intensively. Hence, non-purine-selective xanthine oxidoreductase inhibitors may decrease the incidence of EIAKI in athletes with RHUC.
- 著者
- Toshio NOZAKA Daisuke MIYAMOTO
- 出版者
- Japan Association of Mineralogical Sciences
- 雑誌
- Journal of Mineralogical and Petrological Sciences (ISSN:13456296)
- 巻号頁・発行日
- vol.116, no.6, pp.314-319, 2021 (Released:2022-03-24)
- 参考文献数
- 25
- 被引用文献数
- 1
Compositional variations of talc in peridotites and serpentinites could have significant implications for modeling of geochemical cycles involving the upper mantle but have been scarcely studied. We analyzed chemical compositions of prograde and retrograde talc and associated minerals in thermally metamorphosed serpentinites from Southwest Japan. The analyzed talc has variations of Si, Al, Mg, Fe, and Na contents. Most of the Si, Al, Mg, and Fe variations indicate mechanical mixing with serpentine and chlorite at a submicroscopic scale. Spatial distribution of talc–chlorite mixtures suggests their prograde metamorphic origin. Talc–serpentine mixtures could be formed by retrograde decomposition of talc–olivine assemblage and orthopyroxene at conditions of higher temperature and/or higher Si activity than serpentine–brucite mixtures, which are the typical products of serpentinization of olivine. Talc itself, regardless of prograde or retrograde origin, has compositional variations with Na enrichment as a likely result of solid solution or Na–mica mixing. The Na enrichment suggests that talc could be the most capable reservoir of Na in metamorphosed peridotites and serpentinites.