著者

Eiichi Araki Atsushi Tanaka Nobuya Inagaki Hiroshi Ito Kohjiro Ueki Toyoaki Murohara Kenjiro Imai Masataka Sata Takehiro Sugiyama Hideki Ishii Shunsuke Yamane Takashi Kadowaki Issei Komuro Koichi Node on behalf of the Directors of the JCS and JDS

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.1, pp.82-125, 2020-12-25 (Released:2020-12-25)

参考文献数

293

被引用文献数

16

著者

荒木 英一 Eiichi Araki 桃山学院大学経済学部

出版者

桃山学院大学総合研究所

雑誌

桃山学院大学総合研究所紀要 = ST.ANDREW'S UNIVERSITY BULLETIN OF THE RESEARCH INSTITUTE (ISSN:1346048X)

巻号頁・発行日

vol.35, no.1, pp.33-46, 2009-07-20

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Through the special collaborative research projects (02-R-154, 05-R-181, 08-R-199) funded by Momoyama Gakuin University Research Institute, a considerably wide-ranging business survey has been ongoing since the second quarter of 2004 with the cooperation of the Sakai City Industial Promotion Center. In this article a brief outline of our activities from April 2005 to March 2008 is given fist, and the result of an econometric analysis based on our survey data is discussed. It was discovered that the movements of some diffusion indices of our local regional economy (the south Osaka area) are significantly different from those of some similar indices in "Tankan", the single largest national business survey in Japan conducted by BOJ. The gap between the local and the national indices is widening, which implies that the local companies are becoming increasingly more pessimistic than the government's official statistics suggest. This discovery shows the significance of our unique business survey and the necessity of inquiring into the economic background to the gap.

著者

Seiya Shimoda Rieko Goto Noboru Furukawa Kaku Tsuruzoe Junji Kawashima Shinsuke Iwashita Takako Maeda Shinji Ichimori Kenshi Ichinose Kenro Nishida Eiichi Araki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.16, pp.2091-2096, 2012 (Released:2012-08-15)

参考文献数

33

被引用文献数

3 4

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Objective Several studies have assessed the efficacy of angiotensin receptor blockers (ARBs) on peripheral insulin sensitivity using the euglycemic hyperinsulinemic clamp technique in hypertensive subjects. However, these subjects were mostly non-diabetic, and some studies showed that ARB treatment did not improve insulin sensitivity. Thus, it is still uncertain whether ARBs could improve insulin sensitivity in subjects with hypertension and diabetes. Therefore, we evaluated the effect of olmesartan on peripheral insulin sensitivity in subjects with type 2 diabetes and hypertension using M/I value during the euglycemic-hyperinsulinemic clamp technique. Methods We enrolled 10 Japanese subjects with type 2 diabetes and hypertension who had never taken antihypertensive agents. Their blood pressure, fasting plasma glucose level, HbA1c and glucose utilization rate during euglycemic-hyperinsulinemic clamp (M/I value) were examined before and after 6 months of treatment with 10-20 mg/day olmesartan (mean: 13.0 mg/day). Results Blood pressure decreased significantly from 156/88 mmHg before starting olmesartan to 135/76 mmHg after 6 months of olmesartan treatment. The mean M/I value increased significantly from 6.33±3.19 (mg/kg/min/mU/L) × 100 to 8.11±4.20 (mg/kg/min/mU/L) × 100. Peripheral insulin sensitivity improved in eight out of ten subjects. Fasting glucose levels and HbA1c levels also decreased significantly. Conclusion These results indicate that olmesartan improves glucose metabolism by improving the peripheral insulin sensitivity in subjects with type 2 diabetes.