著者

筒井 正明 奥野 充 藤沢 康弘 小林 哲夫 Tsutsui Masaaki Okuno Mitsuru Fujisawa Yasuhiro Kobayashi Tetsuo

出版者

福岡大学研究推進部

雑誌

福岡大学理学集報 = Fukuoka University Science Reports (ISSN:0386118X)

巻号頁・発行日

vol.49, no.2, pp.89-97, 2019-09

著者

Ishitsuka Yosuke Kawachi Yasuhiro Taguchi Shijima Maruyama Hiroshi Fujisawa Yasuhiro Furuta Junichi Nakamura Yasuhiro Otsuka Fujio

出版者

Nature Publishing Group

雑誌

Journal of investigative dermatology (ISSN:0022202X)

巻号頁・発行日

vol.132, no.7, pp.1775-1784, 2012-07

被引用文献数

14 4

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The epidermis is a self-renewing tissue, the homeostasis of which is dependent upon the tight balance between proliferation and differentiation based on appropriate regulation of the cell cycle. The cell cycle regulation is dependent on the interactions among a number of cell cycle regulatory molecules, including the pituitary tumor-transforming gene 1 (PTTG1), also known as securin, a regulator of sister chromatid separation and transition from metaphase to anaphase. This study was conducted to clarify the less-known functions of PTTG1 in the epidermis by the use of keratinocytes cultured under two-dimensional (2D) or three-dimensional (3D) conditions. Forced overexpression of PTTG1 caused upregulation of cyclin B1, cyclin-dependent kinase 1 (CDK1), and c-Myc, resulting in enhanced proliferation and suppression of early differentiation without apparent alterations in terminal differentiation, and the exogenous PTTG1 was downregulated in association with cell cycle exit. In contrast, depletion of PTTG1 caused their downregulation and constrained proliferation with retention of differentiation capacity. These findings suggested that PTTG1 could alter the proliferation status by modulating the expression levels of the other cell cycle regulatory proteins, and excess PTTG1 primarily affects early differentiation of keratinocytes under the stability regulation associated with cell cycle exit.

著者

Karube Rei Sasaki Hiroyoshi Shinozuka Keiji Fujisawa Yasuhiro Yanagawa Toru Yamagata Kenji Onizaw Kojiro Otsuka Fujio Bukawa Hiroki

出版者

Nature Publishing Group

雑誌

International Journal of Oral Science (ISSN:16742818)

巻号頁・発行日

vol.4, no.3, pp.166-169, 2012-09

被引用文献数

6 2

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Angiosarcoma is an uncommon malignancy, which spread out from the endothelial cells of vessels. Scalp angiosarcoma with cervical lymph node metastasis is particularly rare. This article describes a rare case of angiosarcoma of the scalp, presenting as neck inflammation. Imaging procedures such as computed tomography (CT), magnetic resonance image (MRI) and ultrasonography (US) were not sufficient to diagnose this case. A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis. Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion. Once the angiosarcoma diagnosis was confirmed histologically, sequential weekly and monthly docetaxel (DTX) treatment was effective in preventing reoccurrence. Nonetheless, the optimization of angiosarcoma treatment remains a future goal. Although patients generally describe pain and swelling at the primary lesion site, this patient complained only of painful neck inflammation, without any indication of pain or swelling of the scalp. A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp.