著者

Izumi Yasuhiko Matsumura Atsuko Wakita Seiko Akagi Ken-Ichi Fukuda Hiroyuki Kume Toshiaki Irie Kazuhiro Takada-Takatori Yuki Sugimoto Hachiro Hashimoto Tadashi Akaike Akinori

出版者

Elsevier Inc.

雑誌

Free radical biology & medicine (ISSN:08915849)

巻号頁・発行日

vol.53, no.4, pp.669-679, 2012-06-27

被引用文献数

43

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青ジソから老化やメタボリックシンドローム予防に有望な生体内抗酸化力を高める成分を発見. 京都大学プレスリリース. 2012-08-06.

著者

Sasaki Hiroki Sunagawa Yoichi Takahashi Kenji Imaizumi Atsushi Fukuda Hiroyuki Hashimoto Tadashi Wada Hiromichi Katanasaka Yasufumi Kakeya Hideaki Fujita Masatoshi Hasegawa Koji Morimoto Tatsuya

出版者

公益社団法人 日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.5, pp.660-665, 2011

被引用文献数

334

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Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration–time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.