- 著者
- Matsumori Akira Ohashi Naohiro Nishio Ryosuke Kakio Tadashi Hara Masatake Furukawa Yutaka Ono Koh Shioi Tetsuo Hasegawa Koji Sasayama Shigetake
- 出版者
- 社団法人日本循環器学会
- 雑誌
- Japanese circulation journal (ISSN:00471828)
- 巻号頁・発行日
- vol.63, no.6, pp.433-438, 1999-05-20
- 被引用文献数
- 2 23
The familial of hypertrophic cardiomyopathy(HCM)is attributed to mutations in the genes for contractile proteins, but the etiology of non-familial form remains unknown. This study was designed to examine the clinical features, histopathologic changes, and hepatitis C virus(HCV)genomes in patients with HCM associated with HCV infection. Anti-HCV antibody was present in the sera of 9 of 65 patients(13.8%)with HCM versus 2.41% in a control population of voluntary blood donors in Japan, a statistically significant difference (p<0.0001). Among these 9 patients, 6 had ace-of-spades-spaped deformities of the left ventricle with apical hypertrophy. Myocardial fibrosis was found in all patients, and mild cellular infiltration was observed in 5patients. Type 1b HCV RNA was present in the sera of 5 of the 9 patients. The copy number of HCV was 5.5×10^3-8.6×10^5 genomes/ml serum, and multiple clones of HCV were detected in the sera of each patient by an analysis of the hypervariable regions using fluorescent single-strand conformation polymorphism. Positive strands of HCV were found in the hearts of 5 patients, and negative strands in the hearts of 2 patients. A high prevalence of HCV infection was found in patients with HCM, particularly of the apical variety, suggesting that HCV is an important causal agent in the pathogenesis of the disease.
- 著者
- Horie Takahiro Nishino Tomohiro Baba Osamu Kuwabara Yasuhide Nakao Tetsushi Nishiga Masataka Usami Shunsuke Izuhara Masayasu Nakazeki Fumiko Ide Yuya Koyama Satoshi Sowa Naoya Yahagi Naoya Shimano Hitoshi Nakamura Tomoyuki Hasegawa Koji Kume Noriaki Yokode Masayuki Kita Toru Kimura Takeshi Ono Koh
- 出版者
- Nature Publishing Group
- 雑誌
- Scientific reports (ISSN:20452322)
- 巻号頁・発行日
- vol.4, 2014-06-16
- 被引用文献数
- 44
マウスへのマイクロRNA-33bの導入に成功 -ヒトでのHDL-コレステロールの質の改善に期待-. 京都大学プレスリリース. 2014-06-17.
- 著者
- Arai Tsukasa Toda Yuta Kato Kiyotaka Miyamoto Kensuke Hasegawa Tsuyoshi Yamada Kosumi Ueda Junichi Hasegawa Koji Inoue Tsuyoshi Shigemori Hideyuki
- 出版者
- Elsevier
- 雑誌
- Tetrahedron (ISSN:00404020)
- 巻号頁・発行日
- vol.69, no.34, pp.7001-7005, 2013-08
- 被引用文献数
- 15 1
A new sesquiterpene with an α-methylene-γ-lactone moiety, artabolide (1), and three known derivatives 2–4 were isolated from Artemisia absinthium. The structure of 1 was elucidated by 1D and 2D NMR analyses, and the absolute configuration was determined using the modified Mosher's method and X-ray crystal structural analysis. Approximately 2.5 μg/plant treatment of artabolide (1) exhibited ca. 50% inhibition of polar auxin transport in radish hypocotyls, while 2–4 showed no significant inhibitory activity. Therefore, these results support the importance of the α-methylene-γ-lactone moiety for the inhibition of polar auxin transport.
- 著者
- Sasaki Hiroki Sunagawa Yoichi Takahashi Kenji Imaizumi Atsushi Fukuda Hiroyuki Hashimoto Tadashi Wada Hiromichi Katanasaka Yasufumi Kakeya Hideaki Fujita Masatoshi Hasegawa Koji Morimoto Tatsuya
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.34, no.5, pp.660-665, 2011
- 被引用文献数
- 326
Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration–time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.