- 著者
- Hae-Kwan CHEONG Dae Seob CHOI Keon Uk PARK Jung Ran KIM Kyung-Im HA Hwan Jung YUN Seoung-Oh YANG Yangho KIM
- 出版者
- 独立行政法人 労働安全衛生総合研究所
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- vol.42, no.2, pp.179-188, 2004 (Released:2007-03-29)
- 参考文献数
- 33
- 被引用文献数
- 2 3
This study was conducted to develop a noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters. Six painters with hypocellular marrow and 132 referents were examined using magnetic resonance imaging (MRI). Full examination of the peripheral blood and bone marrow biopsy was done on each patient. Signal indices were calculated from the signal intensities measured at the vertebral bodies from T12 to S1 and on the paraspinal muscles on both the T1- and the T2-weighted image (T1WI and T2WI). Bone marrow cellularities of the painters were between 20.3% and 33.6%. Signal indices at T1WI were greater in the hypocellular marrow cases compared to those of the referents (p<0.05, p<0.01) and were significantly higher in older women compared with men (p<0.05). After adjusting for age and gender, the signal index of cases at S1 of T1WI was higher than that of the referents by 0.364. Five of the six cases had signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender. MRI signal indices can be used as a useful indicator of bone marrow cellularity in a high-risk population after adequate adjustment.
- 著者
- Joung-Soon KIM Hyun-Sul LIM Sung-Il CHO Hae-Kwan CHEONG Min-Kyung LIM
- 出版者
- National Institute of Occupational Safety and Health
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- vol.41, no.3, pp.149-157, 2003 (Released:2007-03-29)
- 参考文献数
- 6
- 被引用文献数
- 63 86
In order to determine whether Agent Orange exposure was associated with increased frequency of medical problems, we conducted a cross-sectional epidemiologic study of Korean veterans during 1995-1996. 1, 224 Vietnam and 154 non-Vietnam veterans were included in the study. Exposure to Agent Orange was assessed by structured in-depth interview on the participants' history of service in Vietnam. Health outcomes were assessed by a standardized comprehensive clinical investigation by a group of clinical specialists. The differences in the prevalence of various medical diagnoses were assessed by Cochran-Mantel-Haenszel chi-square tests comparing the exposure levels of Vietnam veterans, adjusting for age. Multiple logistic regression was performed to estimate the effect of “service in Vietnam” adjusting for age, smoking, alcohol, body mass index, education, and marital status. Vietnam veterans had an increased frequency of eczema (odds ratio [OR]=6.54), radiculopathy (OR=3.98), diabetes (OR=2.69), peripheral neuropathy (OR=2.39), and hypertension (OR=2.29), compared to non-Vietnam veterans, adjusting for potential confounders. In addition, higher levels of exposure among Vietnam veterans were associated with increased frequency of ischemic heart disease (p<0.01), valvular heart disease (p<0.01), and retinopathy (p<0.01). We conclude that exposure to Agent Orange is associated with various health impacts in Korean Vietnam veterans.