著者

Hae-Won JUNG Hee-Chun LEE Ji-Hyun KIM Hyo-Mi JANG Jong-Hyun MOON Jung-Hyang SUR Jeongim HA Dong-In JUNG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0001, (Released:2014-08-13)

被引用文献数

3 12

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An 8-year-old intact male Belgian Malinois, weighing 37.2 kg, was referred for evaluation due to right side facial paresis, ataxia and a two-month history of decreased cognitive ability. Physical and neurological examinations revealed mild depression, left-sided head tilt, right-sided facial paresis and ataxia. A well-demarcated, broad-based cerebellar mass and hyperostosis were found on CT imaging of the brain. Based on these CT findings, a cerebellar meningioma was strongly suspected. Hydroxyurea and prednisolone were administered; after 4 weeks, there was reduction in mass size as compared to initial CT results. However, the mass size was found to have grown 6 weeks after hydroxyurea treatment. We then prescribed a combination of imatinib mesylate and hydroxyurea. Two weeks following combination treatment, the mass size had reduced significantly. The mass continuously decreased in size until the patient died during anesthesia. Cerebellar transitional meningioma was confirmed by histopathologic examination. To the author’s knowledge, this is the first reported case of imatinib mesylate plus hydroxyurea therapy for the treatment of meningioma in veterinary medicine.

著者

Dong-In JUNG Hee-Chun LEE Jeongim HA Hae-Won JUNG Joon-Hyeonk JEON Jong-Hyun MOON Jae-Hoon LEE Na-Hyun KIM Jung-Hyang SUR Byeong-Teck KANG Kyu-Woan CHO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0503, (Released:2013-08-13)

被引用文献数

1 4

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A 4-year-old female Maltese (case 1), a 9-year-old castrated male Shih-Tzu (case 2) and 2-year-old female Pomeranian (case 3) were presented because of neurological signs such as head tilt, ataxia, circling and paresis. Three cases were tentatively diagnosed to meningoencephalitis of unknown etiology based on computed tomography scan and cerebrospinal fluid analysis. All patients were managed with cyclosporine plus prednisolone therapy. The survival times of three patients were 170, 70 and 21 days, respectively. After cases expired, we performed necropsy and histopathological examination for definitive diagnosis. Based on the necropsy, histopathological and immunohistochemical examinations, case 1, 2 and 3 were definitely diagnosed to necrotizing meningoencephalitis, necrotizing leukoencephlaitis and granulomatous meningoencephalitis, respectively. This case report demonstrated that the clinical findings, brain CT characteristics, histopathological and immunohistochemical features of NME, NLE and GME in dogs and discussed about the reason of relatively short survival times under cyclosporine plus prednisolone therapy.