著者
Peng XU Hao CHEN Duoying CUI Chunrong LI Guoyuan CHEN Yongqiang ZHAO Changhu LU
出版者
The Ornithological Society of Japan
雑誌
ORNITHOLOGICAL SCIENCE (ISSN:13470558)
巻号頁・発行日
vol.19, no.1, pp.93-97, 2020 (Released:2020-01-30)
参考文献数
25

The Red-crowned Crane Grus japonensis is an endangered species in East Asia. The western flyway population in China has been in steady decline in recent years because of the loss and deterioration of the natural wetland habitat it requires. To enhance this migratory Red-crowned Crane population, a project was designed to return captive Red-crowned Cranes to the wild in 2013 and 2015 in the Yancheng National Nature Reserve (YNNR). This reserve is the most important wintering site for the continental migratory population. The survival rate of introduced Red-crowned Cranes was 40%. However, aggregation of introduced and wild individuals was not observed. Introduced individuals did not pair with wild individuals nor did they migrate to breeding areas with them. They remained in the core zone of the YNNR over summer. Here, we report the first breeding of introduced Red-crowned Cranes in the YNNR in 2017 and 2018. Suitable rearing methods and the use of aircraft to inform them of the migration route are necessary. Further research is necessary to confirm the migratory status of the cranes that are reared in the reserve.
著者
Jiangang Chen Wenfang Lu Hao Chen Xiaoli Bian Guangde Yang
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
pp.b18-00661, (Released:2018-11-30)
参考文献数
40
被引用文献数
2

In this study, a series of salicylic acid derivatives were designed and synthesized as novel non-saccharide α-glucosidase inhibitors. Biological evaluation indicated that when compared to acarbose, compounds T9, T10, and T32 exhibited a higher potency of α-glucosidase inhibitory activity with IC50 values of 0.15 ± 0.01 mM, 0.086 ± 0.01 mM and 0.32 ± 0.02 mM, respectively. Evaluation of the inhibition kinetics indicated that T9, T10, T32, and acarbose interacted with α-glucosidase in a mixed non-competitive inhibitory manner. Moreover, T9, T10, and T32 statically quenched the fluorescence of α-glucosidase by formation of an inhibitor-α-glucosidase complex. The docking results showed that hydrogen bonds were generated between the test compounds and α-glucosidase. The antioxidant study revealed that compound T10 exhibited a higher antioxidant activity via scavenging 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH), thereby inhibiting lipid peroxidation and the total reduction capacity. In brief, the salicylic acid derivatives identified in this study were promising candidates for development as novel non-saccharide α-glucosidase inhibitors.