著者

Naohiko ONO Yasundo YAMASAKI Noriyuki YAMAMOTO Akihiko SUNAMI Hidekazu MIYAKE

出版者

The Japanese Pharmacological Society

雑誌

The Japanese Journal of Pharmacology (ISSN:00215198)

巻号頁・発行日

vol.42, no.3, pp.431-439, 1986 (Released:2006-09-15)

参考文献数

23

被引用文献数

4 5

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The possible mechanism of the anti-inflammatory activity of proglumetacin maleate (PGM), a new indomethacin (IND) derivative interacting with arachidonic acid (AA) metabolism, was investigated to elucidate the contributions of PGM itself and its two major metabolites, desproglumideproglumetacin maleate (DPP) and IND. PGM caused much less inhibition of PGE2 formation by sheep seminal vesicle microsomes (IC50=310 μM) and TXB2 formation by a washed rabbit platelet suspension (IC50=6.3 μM) than IND. DPP also caused less inhibition of cyclooxygenase than IND. Moreover, PGM had less effect on sodium arachidonate (SAA)-induced rat platelet aggregation ex vivo and AA-induced sudden death in rabbits than IND. These results show that PGM has anti-inflammatory activity after its conversion to the active metabolite IND. However, the inhibitory effects of PGM and DPP were as strong as that of IND on SAA- or collageninduced rabbit platelet aggregation in vitro. These activities are considered to be associated with platelet membrane interaction. Moreover, unlike IND, PGM (IC50=1.5 μM) and DPP (IC50=16.3 μM) strongly inhibited 5-HETE formation by the cytosol of guinea pig polymorphonuclear leukocytes. This unique activity of PGM on 5-lipoxygenase may contribute to its anti-inflammatory activity.

著者

Kin-ya KUBO Yukiko ICHIHASHI Chika KURATA Mitsuo IINUMA Daisuke MORI Tasuku KATAYAMA Hidekazu MIYAKE Shu FUJIWARA Yasuo TAMURA

出版者

オカジマ・フォリア・アナトミカ・ヤポニカ編集部

雑誌

Okajimas Folia Anatomica Japonica (ISSN:0030154X)

巻号頁・発行日

vol.87, no.3, pp.135-140, 2010 (Released:2012-02-10)

参考文献数

88

被引用文献数

5 21

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Recent studies have suggest that masticatory (chewing) function is useful for maintaining neurocognitive function in the elderly. For example, a reduced ability to masticate, such as that resulting from toothlessness or soft-diet feeding, causes learning and memory deficits in aged animals and pathologic changes in the hippocampus. In addition, occlusal disharmony impairs hippocampal memory processes via chronic stress, and induces similar hippocampal pathology. Chewing, however, rescues stress-induced suppression of long-term potentiation in the hippocampus and the stress-induced impairment of hippocampal-dependent learning. These findings strongly suggest a link between mastication and neurocognitive function.