著者

Kin-ya KUBO Yukiko ICHIHASHI Chika KURATA Mitsuo IINUMA Daisuke MORI Tasuku KATAYAMA Hidekazu MIYAKE Shu FUJIWARA Yasuo TAMURA

出版者

オカジマ・フォリア・アナトミカ・ヤポニカ編集部

雑誌

Okajimas Folia Anatomica Japonica (ISSN:0030154X)

巻号頁・発行日

vol.87, no.3, pp.135-140, 2010 (Released:2012-02-10)

参考文献数

88

被引用文献数

5 21

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Recent studies have suggest that masticatory (chewing) function is useful for maintaining neurocognitive function in the elderly. For example, a reduced ability to masticate, such as that resulting from toothlessness or soft-diet feeding, causes learning and memory deficits in aged animals and pathologic changes in the hippocampus. In addition, occlusal disharmony impairs hippocampal memory processes via chronic stress, and induces similar hippocampal pathology. Chewing, however, rescues stress-induced suppression of long-term potentiation in the hippocampus and the stress-induced impairment of hippocampal-dependent learning. These findings strongly suggest a link between mastication and neurocognitive function.