- 著者
- Hiroaki Eshima
- 出版者
- The Japanese Society of Physical Fitness and Sports Medicine
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.9, no.5, pp.199-204, 2020-09-25 (Released:2020-09-16)
- 参考文献数
- 42
- 被引用文献数
- 2
Obesity and aging reduce skeletal muscle contractile function, which represents a reduction in muscle quality. Dysfunction of muscle contraction may contribute to a greater risk for diabetes, cardiovascular diseases, and cancer; therefore, the synergistic effects of obesity and aging on muscle function may exacerbate morbidity and mortality. However, evidence directly examining the synergistic effects of obesity and aging on muscle contractile function is lacking and controversial. We recently demonstrated that diet-induced obesity significantly exacerbates contractile dysfunction in aged skeletal muscle. The focus of this review is the effects of obesity on muscle contractile dysfunction in skeletal muscle, particularly during aging.
- 著者
- Hiroaki Eshima David C Poole Yutaka Kano
- 出版者
- The Japanese Society of Physical Fitness and Sports Medicine
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.7, no.4, pp.205-211, 2018-07-25 (Released:2018-07-18)
- 参考文献数
- 57
- 被引用文献数
- 1
In skeletal muscle, resting cytosolic Ca2+ concentration ([Ca2+]cyto) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Specifically, skeletal muscle contractile function is critically dependent on effective SR Ca2+ handling. However, more recent studies have revealed that mitochondria are essentially involved in [Ca2+]cyto homeostasis during and following muscle contractions. We recently provided substantial support for the mitochondria as a major site for Ca2+ sequestration in skeletal muscle during recovery from fatiguing tetanic contractions under in vivo conditions. This review provides an overview of the role of skeletal muscle mitochondria in [Ca2+]cyto regulation in vivo during and following muscle contractions.