文献一覧: Hiroaki AKIMOTO (著者)

1 0 0 0 OA Role of Curdlan Sulfate in the Binding of HIV-1 gp120 to CD4 Molecules and the Production of gp120-Mediated TNF-α

著者: Nanako Takeda-Hirokawa Lian-Pin Neoh Hiroaki Akimoto Hiroshi Kaneko Takashi Hishikawa Iwao Sekigawa Hiroshi Hashimoto Shun-ichi Hirose Tsutomu Murakami Naoki Yamamoto Tohru Mimura Yutaro Kaneko
出版者: Center For Academic Publications Japan
雑誌: MICROBIOLOGY and IMMUNOLOGY (ISSN:03855600)
巻号頁・発行日: vol.41, no.9, pp.741-745, 1997 (Released:2008-03-17)
参考文献数: 25

To clarify the mechanism by which curdlan sulfate (CRDS) inhibits human immunodeficiency virus (HIV)-1 infection, we examined its influence on the binding of gp120 to CD4 molecules on T cells and macrophages, as well as on the production of TNF-α by gp120-stimulated macrophages (which promotes HIV-1 replication). CRDS treatment of cells not only inhibited the binding of HIV-1 gp120 to CD4+ cells, but also inhibited TNF-α production induced by gp120. Inhibition of HIV-1 infection by CRDS may be related to these two actions.

2023-10-20 02:10:09
1 + 1 Twitter

https://www.jstage.jst.go.jp/article/mandi1977/41/9/41_9_741/_article/-char/ja/

1 0 0 0 OA Role of Curdlan Sulfate in the Binding of HIV-1 gp120 to CD4 Molecules and the Production of gp120-Mediated TNF-α

1 0 0 0 OA The Problem and Solution in the Educational Use of GIS