著者

Ryota Hikiami Hodaka Yamakado Shinsui Tatsumi Takashi Ayaki Yuichiro Hashi Hirofumi Yamashita Nobukatsu Sawamoto Teruyuki Tsuji Makoto Urushitani Ryosuke Takahashi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.13, pp.1917-1919, 2018-07-01 (Released:2018-07-01)

参考文献数

10

被引用文献数

7

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We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger.

著者

Ryota Hikiami Hodaka Yamakado Shinsui Tatsumi Takashi Ayaki Yuichiro Hashi Hirofumi Yamashita Nobukatsu Sawamoto Teruyuki Tsuji Makoto Urushitani Ryosuke Takahashi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0285-17, (Released:2018-02-09)

参考文献数

10

被引用文献数

7

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We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger.

著者

Satoshi Kawato Keigo Kobayashi Sho Shirakashi Soetsu Yanagi Yutaka Fukuda Hirofumi Yamashita Reiko Nozaki Ikuo Hirono Hidehiro Kondo

出版者

The Japanese Society of Fish Pathology

雑誌

魚病研究 (ISSN:0388788X)

巻号頁・発行日

vol.54, no.2, pp.27-33, 2019-06-15 (Released:2019-08-03)

参考文献数

26

被引用文献数

4

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Infection with the skin fluke Benedenia seriolae is a serious threat of yellowtail aquaculture. ​Development of genomic resources and molecular markers for B. seriolae is an essential infrastructure to develop control strategies against B. seriolae infections. ​As a seminal study to establish the genomic resources of the Japanese B. seriolae populations, we sequenced the complete mitochondrial genome (mitogenome) sequences of 12 B. seriolae specimens collected from four prefectures in Japan. ​The Japanese B. seriolae mitogenomes were mutually 99% identical, while the identity was 85% when compared to that of an Australian specimen. ​Furthermore, the gene arrangement in the Japanese B. seriolae mitogenome was slightly different from that in the Australian specimen. ​The substantial mitogenomic divergence between the Australian and Japanese specimens indicates that B. seriolae is composed of molecularly divergent populations. ​Variable sites were dispersed in the mitogenome of the Japanese B. seriolae. ​Phylogenetic relationships among the Japanese B. seriolae specimens did not reflect the host species or geographic distributions within Japan.