著者
Ryota Hikiami Hodaka Yamakado Shinsui Tatsumi Takashi Ayaki Yuichiro Hashi Hirofumi Yamashita Nobukatsu Sawamoto Teruyuki Tsuji Makoto Urushitani Ryosuke Takahashi
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.57, no.13, pp.1917-1919, 2018-07-01 (Released:2018-07-01)
参考文献数
10
被引用文献数
1

We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger.

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外部データベース (DOI)

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症例報告(京大):15歳女性、HPVワクチン接種後に筋萎縮性側索硬化症 (ALS)を発症し死亡。ALS原因遺伝子の一つFUS遺伝子に変異があった。「ワクチンがALS発症の引き金になった可能性は否定できない。ワクチンが安全かどうか結… https://t.co/g0uc2NqfYa
HPVワクチン接種後にALSを発症し、亡くなった15歳の少女についての症例報告 https://t.co/zzqorLUxDD 。abstractを見ると、「HPVワクチンが引き金となった可能性を完全に排除できない」とあるものの、FUS遺伝子変異によるALSと診断した、と。
国内症例報告 【Intern Med】 Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report… https://t.co/TmAbvmXBmh

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