文献一覧: Hiromi Kumon (著者)

1 0 0 0 OA Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder

著者: Hiroaki Kurahashi Masami Watanabe Morito Sugimoto Yuichi Ariyoshi Sabina Mahmood Motoo Araki Kazushi Ishii Yasutomo Nasu Atsushi Nagai Hiromi Kumon
出版者: The Japan Endocrine Society
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: vol.60, no.12, pp.1321-1327, 2013 (Released:2013-12-27)
参考文献数: 23
被引用文献数: 4 39

Gender identity disorder (GID) results from a disagreement between a person’s biological sex and the gender to which he or she identifies. With respect to the treatment of female to male GID, testosterone replacement therapy (TRT) is available. The uric acid (UA) level can be influenced by testosterone; however, the early effects and dose-dependency of TRT on the serum UA concentration have not been evaluated in this population. We herein conducted a dose-response analysis of TRT in 160 patients with female to male GID. The TRT consisted of three treatment groups who received intramuscular injections of testosterone enanthate: 125 mg every two weeks, 250 mg every three weeks and 250 mg every two weeks. Consequently, serum UA elevation was observed after three months of TRT and there was a tendency toward testosterone dose-dependency. The onset of hyperuricemia was more prevalent in the group who received the higher dose. We also demonstrated a positive correlation between increased levels of serum UA and serum creatinine. Since the level of serum creatinine represents an individual’s muscle volume and the muscle is a major source of purine, which induces UA upregulation, the serum UA elevation observed during TRT is at least partially attributed to an increase in muscle mass. This is the first study showing an association between serum UA elevation and a TRT-induced increase in muscle mass. The current study provides important information regarding TRT for the follow-up and management of the serum UA levels in GID patients.

2018-08-01 20:36:26
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1 0 0 0 OA Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder

著者: Aya Nakamura Masami Watanabe Morito Sugimoto Tomoko Sako Sabina Mahmood Haruki Kaku Yasutomo Nasu Kazushi Ishii Atsushi Nagai Hiromi Kumon
出版者: (社)日本内分泌学会
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: vol.60, no.3, pp.275-281, 2013 (Released:2013-03-31)
参考文献数: 11
被引用文献数: 7 68

Gender identity disorder (GID) is a conflict between a person’s actual physical gender and the one they identify him or herself with. Testosterone is the key agent in the medical treatment of female to male GID patients. We conducted a dose-response analysis of testosterone replacement therapy (TRT) in 138 patients to determine the onset of the therapeutic effects. The TRT consisted of intramuscular injection of testosterone enanthate and patients were divided into three groups; 250 mg every two weeks, 250 mg every three weeks and 125 mg every two weeks. The onset of deepening of voice, increase in facial hair and cessation of menses was evaluated in each group. At one month after the start of TRT, the onset of these physical changes was more prevalent in the group receiving the higher dose of testosterone, and there were dose-dependent effects observed between the three treatment groups. On the other hand, at six months after the start of TRT, most of the patients had achieved treatment responses and there were no dose-dependent effects with regard to the percentage of patients with therapeutic effects. No significant side effects were observed in any of the treatment groups. We demonstrated that the early onset of the treatment effects of TRT is dose-dependent, but within six months of starting TRT, all three doses were highly effective. Current study provides useful information to determine the initial dose of TRT and to suggest possible changes that should be made in the continuous dosage for long term TRT.

2013-10-10 10:18:51
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1 0 0 0 OA Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder

著者: Hiroaki Kurahashi Masami Watanabe Morito Sugimoto Yuichi Ariyoshi Sabina Mahmood Motoo Araki Kazushi Ishii Yasutomo Nasu Atsushi Nagai Hiromi Kumon
出版者: (社)日本内分泌学会
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: pp.EJ13-0203, (Released:2013-09-18)
被引用文献数: 1 39

2013-09-21 20:26:12
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1 0 0 0 OA Urinary Excretion of Anthocyanins in Humans after Cranberry Juice Ingestion

著者: Ryoko OHNISHI Hideyuki ITO Naoki KASAJIMA Miyuki KANEDA Reiko KARIYAMA Hiromi KUMON Tsutomu HATANO Takashi YOSHIDA
出版者: Japan Society for Bioscience, Biotechnology, and Agrochemistry
雑誌: Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
巻号頁・発行日: vol.70, no.7, pp.1681-1687, 2006-07-23 (Released:2006-07-23)
参考文献数: 42
被引用文献数: 76

Cranberry, which is rich in polyphenols, including anthocyanins and proanthocyanidins, has been found to have various effects beneficial to human health, including prevention of urinary tract infections. These effects have been associated with polyphenols in the fruit. We investigated the excretion of anthocyanins in human urine after ingestion of cranberry juice. Eleven healthy volunteers consumed 200 ml of cranberry juice containing 650.8 μg total anthocyanins. Urine samples were collected within 24 h before and after consumption. Six of 12 anthocyanins identified in cranberry were quantified in human urine by HPLC coupled with electrospray ionization and tandem mass spectrometry (HPLC–ESI–MS–MS). Among these, peonidin 3-O-galactoside, the second most plentiful anthocyanin in the juice, was found most abundantly in urine within 24 h, corresponding to 41.5 nmol (56.1% of total anthocyanins). The urinary levels of anthocyanins reached a maximum between 3 and 6 h after ingestion, and the recovery of total anthocyanins in the urine over 24 h was estimated to be 5.0% of the amount consumed. This study found high absorption and excretion of cranberry anthocyanins in human urine.

2013-05-20 20:43:42
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