著者

Kazutoshi Fujibayashi Hiroshi Fukuda Hirohide Yokokawa Tomomi Haniu Fukuko Oka Miki Ooike Toshiaki Gunji Noriko Sasabe Mitsue Okumura Kimiko Iijima Teruhiko Hisaoka Hiroshi Isonuma

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.19, no.10, pp.932-940, 2012 (Released:2012-10-29)

参考文献数

42

被引用文献数

22 28

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Aim: The aim was to investigate the respective associations between lifestyle and proteinuria and the estimated glomerular filtration rate (eGFR).Methods: The lifestyle habits of 25,493 middle-aged participants were investigated in a cross-sectional study to find habits that are associated with a low eGFR (<60 mL/min/1.73 m2) and/or the presence of proteinuria. The lifestyle habits of the participants were evaluated using a questionnaire. Unhealthy lifestyle habits were defined as follows: 1. obesity, 2. being a current/former smoker, 3. eating irregular meals, 4. having less than 5 hours sleep, 5. exercising less than once a week, and 6. drinking more than once a week. The associations among unhealthy habits, eGFR, and proteinuria were evaluated using multivariate analysis.Results: The following lifestyle factors were significantly and independently associated with proteinuria: obesity (odds ratio (OR): 1.18, 95%C.I: 1.04-1.34), being a current/former smoker (OR: 1.26, 95%C.I: 1.11-1.42), eating irregular meals (OR: 1.40, 95%C.I: 1.22-1.61), sleeping less than 5 hours (OR: 1.38, 95%C.I: 1.15-1.65), and exercising less than once a week (OR: 1.18, 95%C.I: 1.05-1.33). In contrast, the following unhealthy lifestyle factors were not clearly associated with a low eGFR: obesity (OR: 1.05, 95%C.I: 0.95-1.17), being a current/former smoker (OR: 0.76, 95%C.I: 0.69-0.84), eating irregular meals (OR: 0.91, 95%C.I: 0.79-1.04), sleeping less than 5 hours (OR: 1.02, 95%C.I: 0.85-1.22), and exercising less than once a week (OR: 0.91, 95%C.I: 0.83-0.99).Conclusion: Associations between proteinuria and unhealthy lifestyle habits were observed in our cross-sectional study. Unhealthy lifestyles should be monitored during the management of CKD patients with proteinuria.

著者

磯田 恵子 松崎 孝世 吉田 禎宏 藤野 良三 斎藤 勢也 高橋 正倫 Naohiko HAYASHI Hiroshi FUKUDA Kunimi HAMADA Naohiko KUROKAMI Takashi NAGANO

出版者

Japan Surgical Association

雑誌

日本臨床外科医学会雑誌 (ISSN:03869776)

巻号頁・発行日

vol.50, no.11, pp.2453-2457, 1989-11-25 (Released:2009-04-21)

参考文献数

14

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最近経験した胆嚢ポリープ癌の4例を報告するとともに,過去10年間に当院外科で手術した胆嚢ポリープ様病変について検討した.内訳はコレステロールポリープ4例,腺腫3例,過形成1例,腺癌4例であった.切除標本ではコレステロールポリープは5mm以下の小病変が多く腺癌は1例を除き10mm以上であった.超音波検査では12例中10例に病変を描出しえており,コレステロールポリープはIaないしIIa型であり,IV型は全て腺癌であった.超音波検査で胆嚢内にポリープ様病変を認めた場合,5mm以下のもの及び5~10mmでもエコーパターンがI型のものは経過観察,II, III, IV型は悪性の可能性もあり手術適応である.また,10mm以上のものは手術を原因とする.手術を施行する際の術式として,術後に癌と判明した場合m, pmの早期癌では胆嚢摘出術のみでよいが,ss以上の進行癌では積極的に再手術を勧めるべきと考えられる.

著者

Kazutoshi Fujibayashi Hirohide Yokokawa Toshiaki Gunji Noriko Sasabe Mitsue Okumura Kimiko Iijima Tomomi Haniu Teruhiko Hisaoka Hiroshi Fukuda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.7, pp.717-723, 2015 (Released:2015-04-01)

参考文献数

27

被引用文献数

1 5

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Objective The aim of this study was to investigate the associations between the incidence of diabetes and the accumulation of markers of impaired glucose metabolism; i.e., pre-diabetes. Methods This retrospective cohort study recruited 1,631 men without diabetes at baseline who attended more than two routine health check-ups at our institution between 2006 and 2012. The participants were divided into four groups based on the number of markers of impaired glucose metabolism exhibited at the initial examination. The following markers of impaired glucose metabolism were defined as risk factors for diabetes: a fasting plasma glucose level of ≥110 mg/dL, 2-hour plasma glucose level of ≥140 mg/dL and glycated hemoglobin (HbA1c) value of ≥6.0% (42 mmol/moL). The risk of developing diabetes was assessed using a multivariate analysis. Results The median examination interval was 1,092 days. The incidence of diabetes rose in association with the number of markers. The subjects with two markers displayed a multivariate-adjusted odds ratio (OR) for diabetes of 19.43 [95% confidence interval (CI): 9.70-38.97] and the subjects with three markers displayed an OR of 48.30 (95% CI: 20.39-115.85) compared with the subjects with one or no markers. Conclusion The present results demonstrate the impact of accumulating markers of impaired glucose metabolism on the risk of developing diabetes. Anti-diabetes intervention strategies should aim to comprehensively assess an individual's risk of developing diabetes at the pre-diabetes stage.