著者

Erwin Suwendi Hitoshi Iwaya Jae-Sung Lee Hiroshi Hara Satoshi Ishizuka

出版者

Biomedical Research Press

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.33, no.6, pp.329-336, 2012 (Released:2012-12-27)

参考文献数

28

被引用文献数

19 22

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Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) as a control or Zndeficient (ZD, 5 mg Zn/kg diet) diet for 21 days and then treated with 2% DSS via deionized drinking water for 7 days. The disease activity index (DAI) was recorded daily throughout DSS treatment. Serum Zn concentrations were significantly lowered in rats fed the ZD diet than those fed the ZA diet at day 7 and 14. Surprisingly, DSS treatment considerably reduced the serum Zn in both groups. The rats fed the ZD diet showed exacerbated colitis based on clinical outcomes, including weight loss, increased DAI, and shortened colon length. An in vitro study corroborated these results, showing that a large amount of TNFα was induced by rat mesenteric leukocytes in response to lipopolysaccharide in ZD medium, but not in ZA medium. These results indicate that a modulation of TNFα production due to Zn deficiency influences disease activity in DSS-induced colitis. In addition, more attention should be given to Zn for prevention of colitis.

著者

Megumi MATSUMOTO Ryo INOUE Takamitsu TSUKAHARA Kazunari USHIDA Hideyuki CHIJI Noritaka MATSUBARA Hiroshi HARA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

pp.0801080740-0801080740, (Released:2008-02-07)

参考文献数

20

被引用文献数

250

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The effects of voluntary wheel-running exercise on cecal microbiota and short-chain fatty acid production were investigated in rats. The microbiota composition was notably different between the exercised and sedentary rats. Furthermore, the exercised rats showed a significantly higher n-butyrate concentration than the sedentary rats. This alteration of the cecal microbial environment may contribute to the beneficial effect of exercise on gastrointestinal disorders.

著者

Ichiro WAKABAYASHI Kunihiro SAKAMOTO Hidehisa MASUI Sachiko YOSHIMOTO Akihisa KANAMARU Eizo KAKISHITA Hiroshi HARA Masashi SHIMO-OKA Kiyoyasu NAGAI

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.33, no.4, pp.198-203, 1994 (Released:2006-03-27)

参考文献数

22

被引用文献数

10 17

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A case control study was performed with 142 leukemia patients and 284 controls matched for age and sex. Occupation, birth order, past medical history, and drinking and smoking habits were compared in these two groups. Persons born first or fourth were found to have a higher incidence of leukemia. History of a fracture was one of the risk factors for acute leukemia, and a history of gastroduodenal ulcer was a risk factor for chronic leukemia. This may suggest that extensive exposure to X-rays in diagnosis and treatment is a risk factor for leukemia. There was a significant dose-response relationship between the amount of smoking and the incidence of acute nonlymphocytic leukemia, but not between the amount of alcohol consumption and the incidence of leukemia. Thus, smoking was one of the risk factors for acute leukemia.(Internal Medicine 33:198-203, 1994)

著者

Hiroshi Hara

出版者

The Botanical Society of Japan

雑誌

植物学雑誌 (ISSN:0006808X)

巻号頁・発行日

vol.48, no.576, pp.889-906, 1934 (Released:2007-05-24)