- 著者
- Shin'ichi KUDO Keiko YOSHIMOTO Hiroshige FURUTA Kazumasa INOUE Masahiro FUKUSHI Fumiyoshi KASAGI
- 出版者
- 日本保健物理学会
- 雑誌
- 保健物理 (ISSN:03676110)
- 巻号頁・発行日
- vol.53, no.3, pp.146-153, 2018 (Released:2018-11-27)
- 参考文献数
- 41
- 被引用文献数
- 7
Whether exposure to radiation at low dose and at low dose rate is related to leukemia mortality and morbidity remains controversial. Cohort studies of nuclear workers chronically exposed to radiation at low dose and at low dose rate in their workplaces provide an opportunity to directly evaluate the risks of leukemia in the lower dose ranges. Previous findings have come mostly from Western countries, with few from Asian countries. The present study aimed to examine radiation’s effects on mortality from leukemia, in a cohort of Japanese nuclear workers. The cohort consisted of 204,103 workers, who were followed from 1991 to 2010, with a total of 2.89 million person-years. The mean age and mean cumulative dose at the age at the end of follow-up were 55.6 years and 13.8 mSv. During the study, 209 leukemia deaths were observed. The linear excess relative risk (ERR) for all types of leukemia was negative, but not significant (ERR/Sv = -0.54; 90% confidence interval; -4.04, 2.96). Specific types of leukemia also showed no significant risks. A significant radiation-leukemia association for mortality was not observed in this study of Japanese nuclear workers. The cohort, however, is still young. Further follow-up is needed to obtain more reliable estimates of leukemia risks for Japanese workers exposed to low dose and low-dose rate radiation.
- 著者
- Shin’ichi KUDO Akemi NISHIDE Jun’ichi ISHIDA Keiko YOSHIMOTO Hiroshige FURUTA Fumiyoshi KASAGI
- 出版者
- Japan Health Physics Society
- 雑誌
- 保健物理 (ISSN:03676110)
- 巻号頁・発行日
- vol.55, no.1, pp.32-39, 2020-04-01 (Released:2020-05-21)
- 参考文献数
- 26
- 被引用文献数
- 2 2
The health effects of low-dose or low-dose rate of radiation are still controversial. There is little evidence to show if radiation risk is greater than other risks, such as lifestyle or socio-economic factors, including smoking. This study aimed to directly compare radiation and smoking risk on cancer mortality by deriving both risk factors simultaneously from one cohort. The study population was Japanese nuclear workers who were engaged until the end of March, 1999. A lifestyle questionnaire was distributed in 1997 and 2003 and smoking information was obtained. Radiation dose was supplied by Radiation Dose Registration Center in Radiation Effects Association. Poisson regression was used to derive radiation excess relative risk (ERR) per 100 mSv and smoking (ERR) per 20 pack-years. Radiation doses were lagged by 10 years. There were 71,733 subjects. The total person-years was 591,000, and the number of deaths for all cancers excluding leukemia was 1,326. For all cancers excluding leukemia, the ERR of radiation per 100 mSv was 0.08 (90% CI: −0.08, 0.28), and the ERR of smoking per 20 pack-years was 0.57 (90% CI: 0.44, 0.73). In addition to all cancers excluding leukemia, stomach cancer, lung cancer, smoking-related cancers showed significantly smaller radiation ERRs than smoking ERRs. These results suggest that, even if a low-dose radiation risk existed, it was much smaller than smoking risk.