- 著者
- Yuusuke SAITSU Akemi NISHIDE Kenji KIKUSHIMA Kuniyoshi SHIMIZU Koichiro OHNUKI
- 出版者
- Biomedical Research Press
- 雑誌
- Biomedical Research (ISSN:03886107)
- 巻号頁・発行日
- vol.40, no.4, pp.125-131, 2019-08-01 (Released:2019-08-14)
- 参考文献数
- 42
- 被引用文献数
- 29
Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body of H. erinaceus for 12 weeks. We performed three kinds of tests: Mini Mental State Examination (MMSE), Benton visual retention test, and Standard verbal paired-associate learning test (S-PA). MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration. We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far.
- 著者
- Shin’ichi KUDO Akemi NISHIDE Jun’ichi ISHIDA Keiko YOSHIMOTO Hiroshige FURUTA Fumiyoshi KASAGI
- 出版者
- Japan Health Physics Society
- 雑誌
- 保健物理 (ISSN:03676110)
- 巻号頁・発行日
- vol.55, no.1, pp.32-39, 2020-04-01 (Released:2020-05-21)
- 参考文献数
- 26
- 被引用文献数
- 2 2
The health effects of low-dose or low-dose rate of radiation are still controversial. There is little evidence to show if radiation risk is greater than other risks, such as lifestyle or socio-economic factors, including smoking. This study aimed to directly compare radiation and smoking risk on cancer mortality by deriving both risk factors simultaneously from one cohort. The study population was Japanese nuclear workers who were engaged until the end of March, 1999. A lifestyle questionnaire was distributed in 1997 and 2003 and smoking information was obtained. Radiation dose was supplied by Radiation Dose Registration Center in Radiation Effects Association. Poisson regression was used to derive radiation excess relative risk (ERR) per 100 mSv and smoking (ERR) per 20 pack-years. Radiation doses were lagged by 10 years. There were 71,733 subjects. The total person-years was 591,000, and the number of deaths for all cancers excluding leukemia was 1,326. For all cancers excluding leukemia, the ERR of radiation per 100 mSv was 0.08 (90% CI: −0.08, 0.28), and the ERR of smoking per 20 pack-years was 0.57 (90% CI: 0.44, 0.73). In addition to all cancers excluding leukemia, stomach cancer, lung cancer, smoking-related cancers showed significantly smaller radiation ERRs than smoking ERRs. These results suggest that, even if a low-dose radiation risk existed, it was much smaller than smoking risk.