- 著者
- Kazutaka Tachibana Ikuhiro Imaoka Takuya Shiraishi Hitoshi Yoshino Mitsuaki Nakamura Masateru Ohta Hiromitsu Kawata Kenji Taniguchi Nobuyuki Ishikura Toshiaki Tsunenari Hidemi Saito Masahiro Nagamuta Toshito Nakagawa Kenji Takanashi Etsuro Onuma Haruhiko Sato
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.57, no.10, pp.1178, 2009-10-01 (Released:2009-10-03)
- 著者
- Kazutaka Tachibana Ikuhiro Imaoka Takuya Shiraishi Hitoshi Yoshino Mitsuaki Nakamura Masateru Ohta Hiromitsu Kawata Kenji Taniguchi Nobuyuki Ishikura Toshiaki Tsunenari Hidemi Saito Masahiro Nagamuta Toshito Nakagawa Kenji Takanashi Etsuro Onuma Haruhiko Sato
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.56, no.11, pp.1555-1561, 2008-11-01 (Released:2008-11-01)
- 参考文献数
- 21
- 被引用文献数
- 14 20
The 3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethylthiohydantoin derivatives which have carboxy-terminal side chains were synthesized and their agonistic/antagonistic activities against androgen receptor (AR) measured. Among them, compound 13b showed antagonistic activity (IC50=130 nM) with no agonistic activity even at 10000 nM. This compound exhibited significant metabolic stability and oral antiandrogenic activity (ED50=7 mg/kg).
- 著者
- Hitoshi YOSHINO
- 出版者
- The Institute of Electronics, Information and Communication Engineers
- 雑誌
- IEICE TRANSACTIONS on Communications (ISSN:09168516)
- 巻号頁・発行日
- vol.E95-B, no.4, pp.1036-1043, 2012-04-01
Cognitive radio is an emerging technology to further improve the efficiency of spectrum use. Due to the nature of the technology, it has many facets, including its enabling technologies, its implementation issues and its regulatory implications. In ITU-R (International Telecommunications Union – Radiocommunication sector), cognitive radio systems are currently being studied so that ITU-R can have a clear picture on this new technology and its potential regulatory implications, from a viewpoint of global spectrum management. This paper introduces the recent results of the ITU-R studies on cognitive radio on both regulatory and technical aspects. This paper represents a personal opinion of the author, but not an official view of the ITU-R.