- 著者
- Gotoh Shimpei Ito Isao Nagasaki Tadao Yamamoto Yuki Konishi Satoshi Korogi Yohei Matsumoto Hisako Muro Shigeo Hirai Toyohiro Funato Michinori Mae Shin-Ichi Toyoda Taro Sato-Otsubo Aiko Ogawa Seishi Osafune Kenji Mishima Michiaki
- 出版者
- Elsevier Inc.
- 雑誌
- Stem cell reports (ISSN:00928674)
- 巻号頁・発行日
- vol.3, no.3, pp.394-403, 2014-09-09
- 被引用文献数
- 254
ヒトiPS細胞から肺胞上皮細胞を分化誘導し、単離する方法を確立 -肺の再生/創薬研究につながる大きな一歩-. 京都大学プレスリリース. 2014-08-22.
- 著者
- Kawakami Ryosuke Dobi Alice Shigemoto Ryuichi Ito Isao
- 出版者
- Public Library of Science
- 雑誌
- PLoS ONE (ISSN:19326203)
- 巻号頁・発行日
- vol.4, no.3, 2008-04-16
Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-D-aspartate receptor (NMDAR) subunit GluRε2 (NR2B) in hippocampal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.