- 著者
- Yoshizato Tetsuichi Dumitriu Bogdan Hosokawa Kohei Makishima Hideki Yoshida Kenichi Townsley Danielle Sato-Otsubo Aiko Sato Yusuke Liu Delong Suzuki Hiromichi Wu Colin O Shiraishi Yuichi Clemente Michael J Kataoka Keisuke Shiozawa Yusuke Okuno Yusuke Chiba Kenichi Tanaka Hiroko Nagata Yasunobu Katagiri Takamasa Kon Ayana Sanada Masashi Scheinberg Phillip Miyano Satoru Maciejewski Jaroslaw P Nakao Shinji Young Neal S Ogawa Seishi
- 出版者
- Massachusetts Medical Society
- 雑誌
- The New England journal of medicine (ISSN:00284793)
- 巻号頁・発行日
- vol.373, no.1, pp.35-47, 2015-07-02
- 被引用文献数
- 456
再生不良性貧血における遺伝子変異の解明 -白血病発症にいたる過程を初めて解明-. 京都大学プレスリリース. 2015-07-09.
- 著者
- Gotoh Shimpei Ito Isao Nagasaki Tadao Yamamoto Yuki Konishi Satoshi Korogi Yohei Matsumoto Hisako Muro Shigeo Hirai Toyohiro Funato Michinori Mae Shin-Ichi Toyoda Taro Sato-Otsubo Aiko Ogawa Seishi Osafune Kenji Mishima Michiaki
- 出版者
- Elsevier Inc.
- 雑誌
- Stem cell reports (ISSN:00928674)
- 巻号頁・発行日
- vol.3, no.3, pp.394-403, 2014-09-09
- 被引用文献数
- 255
ヒトiPS細胞から肺胞上皮細胞を分化誘導し、単離する方法を確立 -肺の再生/創薬研究につながる大きな一歩-. 京都大学プレスリリース. 2014-08-22.
- 著者
- Hira Asuka Yabe Hiromasa Yoshida Kenichi Okuno Yusuke Shiraishi Yuichi Chiba Kenichi Tanaka Hiroko Miyano Satoru Nakamura Jun Kojima Seiji Ogawa Seishi Matsuo Keitaro Takata Minoru Yabe Miharu
- 出版者
- American Society of Hematology
- 雑誌
- Blood (ISSN:00064971)
- 巻号頁・発行日
- 2013-09-13
- 被引用文献数
- 146
「アルデヒド分解酵素遺伝子」ALDH2が解き明かす難病の謎. 京都大学プレスリリース. 2013-09-13
- 著者
- Sakata-Yanagimoto Mamiko Nakagami-Yamaguchi Etsuko Saito Toshiki Kumano Keiki Yasutomo Koji Ogawa Seishi Kurokawa Mineo Chiba Shigeru
- 出版者
- The National Academy of Sciences of the USA
- 雑誌
- Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
- 巻号頁・発行日
- vol.105, no.22, pp.7839-7844, 2008-06
- 被引用文献数
- 52 33
Mast cells are thought to participate in a wide variety of pathophysiological conditions. Mechanisms of regulation, however, of mast cell production and maturation are still to be elucidated. Mast cell developmental process is likely to be profoundly affected by cell-autonomous transcriptional regulators such as the GATA family and CCAAT/enhancer binding protein (C/EBP) family members. Extracellular regulators such as stem cell factor and IL-3 have essential roles in basal and inducible mast cell generation, respectively. The relationship, however, between the extracellular signaling and cellular transcriptional control is unclear, and the trigger of the mast cell development remains elusive. Notch signaling plays a fundamental role in the lymphopoietic compartment, but its role in myeloid differentiation is less clear. Here, we demonstrate that Notch signaling connects environmental cues and transcriptional control for mast cell fate decision. Delta1, an established Notch ligand, instructs bone marrow common myeloid progenitors and granulocyte-macrophage progenitors toward mast cell lineage at the expense of other granulocyte-macrophage lineages, depending on the function of the Notch2 gene. Notch2 signaling results in the up-regulation of Hes-1 and GATA3, whereas simultaneous overexpression of these transcription factors remarkably biases the progenitor fate toward the mast cell-containing colony-forming cells. C/EBPα mRNA was down-regulated in myeloid progenitors as a consequence of Hes-1 overexpression, in agreement with the recent proposal that the down-regulation of C/EBPα is necessary for mast cell fate determination. Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3.