著者

Yudi ZHANG Debiao HE Xinyi HUANG Ding WANG Kim-Kwang Raymond CHOO Jing WANG

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E103.D, no.2, pp.188-195, 2020-02-01 (Released:2020-02-01)

参考文献数

31

被引用文献数

16

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Unlike black-box cryptography, an adversary in a white-box security model has full access to the implementation of the cryptographic algorithm. Thus, white-box implementation of cryptographic algorithms is more practical. Nevertheless, in recent years, there is no white-box implementation for public key cryptography. In this paper, we propose the first white-box implementation of the identity-based signature scheme in the IEEE P1363 standard. Our main idea is to hide the private key to multiple lookup tables, so that the private key cannot be leaked during the algorithm executed in the untrusted environment. We prove its security in both black-box and white-box models. We also evaluate the performance of our white-box implementations, in order to demonstrate utility for real-world applications.

著者

Meng Zhou Zihao Wang Jing Wang Zhe Dong

出版者

Fuji Technology Press Ltd.

雑誌

Journal of Advanced Computational Intelligence and Intelligent Informatics (ISSN:13430130)

巻号頁・発行日

vol.26, no.3, pp.342-354, 2022-05-20 (Released:2022-05-20)

参考文献数

30

被引用文献数

10

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This paper proposes a hybrid path planning and formation control strategy for multi-robots in a dynamic environment. Under a leader-follower formation structure, the followers can track the motion of one leader after the leader’s path is determined. First, a hybrid path planning strategy that contains global path planning and local path planning of the leader is investigated, in which an improved hybrid grey wolf optimizer with whale optimizer algorithm (GWO-WOA) is designed for the global path planning in a given map, meanwhile, a dynamic window approach (DWA) is fused for the local path planning to avoid dynamic obstacles. Then, a leader-follower formation control algorithm is proposed for multiple mobile robots. The followers are controlled to track their corresponding virtual robots which are generated according to the leader’s position and the formation. Finally, simulation experiments are given to demonstrate the feasibility and effectiveness of the proposed algorithm in different environments.

著者

Shuo Wang Guohong Zhang Jing Wang Zhiqiang Ye Huikun Liu Lingyao Guan Yijuan Qiao Jiayu Chen Tao Zhang Qian Zhao Yu Zhang Bo Wang Ya Gao Puyi Qian Lingyan Feng Fang Chen Gongshu Liu

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.1, pp.44-52, 2022-01-05 (Released:2022-01-05)

参考文献数

28

被引用文献数

4

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Background: To investigate the causal link between early-life exposures and long-term health consequences, we established the Tianjin Birth Cohort (TJBC), a large-scale prospective cohort in northern China.Methods: TJBC aims to enroll 10,000 families with follow-ups from pregnancy until children’s six year-old. Pregnant women and their spouses were recruited through a three-tier antenatal healthcare system at early pregnancy, with follow-ups at mid-pregnancy, late pregnancy, delivery, 42 days after delivery, 6 months after delivery, and each year until 6 years old. Antenatal/neonatal examination, biological samples and questionnaires were collected.Results: From August 2017 to January 2019, a total of 3,924 pregnant women have already been enrolled, and 1,697 women have given birth. We observed the prevalence of gestational diabetes mellitus as 18.1%, anemia as 20.4%, and thyroid hypofunction as 2.0%. In singleton live births, 5.6% were preterm birth (PTB), 3.7% were low birth weight, and 7.3% were macrosomia. Based on current data, we also identified maternal/paternal factors which increased the risk of PTB, including paternal age (OR 1.07; 95% CI, 1.01–1.14 for each year increase), vaginal bleeding during pregnancy (OR 2.82; 95% CI, 1.54–5.17) and maternal early-pregnancy BMI (OR 1.08; 95% CI, 1.01–1.15 for each kg/m2 increase).Conclusion: TJBC has the strength of collecting comprehensive maternal, paternal, and childhood information. With a diverse range of biological samples, we are also engaging with emerging new technologies for multi-omics research. The study would provide new insight into the causal link between macro/micro-environmental exposures of early life and short/long-term health consequences.

著者

Huan Ding Jing-jing Wang Xiao-Ya Zhang Lei Yin Tao Feng

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.44, no.3, pp.379-388, 2021-03-01 (Released:2021-03-01)

参考文献数

28

被引用文献数

25

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Lipopolysaccharide (LPS)-induced inflammation is the leading cause of multiple organ failure in sepsis. Pyruvate kinase 2 (PKM2) is a protein kinase and transcriptional coactivator that plays an important role in glycolysis. Recent studies have confirmed that glycolysis maintains the M1 differentiation and induces immune activation in macrophages. Lycium barbarum polysaccharide (LBP), the main bioactive component of Chinese wolfberry, suppresses glycolysis and inflammation. Here, RAW264.7 macrophages were treated with LBP for evaluating its effects against LPS-induced inflammation. The differentiation of M1/M2 macrophages was assessed by flow cytometry for assessing the cell surface markers, CD86 and CD206. The enrichment of hypoxia inducible factor (HIF)-1α and ubiquitin in the PKM2 protein complex was determined by co-immunoprecipitation. LBP suppressed LPS-induced glycolysis, differentiation of M1 macrophages, and the production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and high mobility group (HMG) 1 proteins. The suppressive effects of LBP were similar to those of PKM2 knockdown, but were abolished by the overexpression of PKM2. LPS elevated the mRNA and protein levels of PKM2. LBP reduced the LPS-induced expression of PKM2 protein, but had no effects on the expression of PKM2 mRNA. LPS inhibited the ubiquitination of PKM2, probably by downregulating the expression of ubiquitin ligases, including Nedd4L, Nedd4, and Gnb2. LBP interfered with the inhibition of PKM2 ubiquitination by upregulating the expression of Nedd4L, Nedd4, and Gnb2. In conclusion, LBP suppressed the LPS-induced inflammation by altering glycolysis and the M1 differentiation of macrophages. The effects of LBP were mediated by the downregulation of PKM2 via enhanced ubiquitination.

著者

Chi Cai Wei Hua Li-Gang Ding Jing Wang Ke-Ping Chen Xin-Wei Yang Zhi-Min Liu Shu Zhang

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.78, no.12, pp.2899-2907, 2014-11-25 (Released:2014-11-25)

参考文献数

24

被引用文献数

8 20

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Background:The effect of adiposity on response to cardiac resynchronization therapy (CRT) and long-term outcome in patients undergoing CRT has not been previously reported. This study assessed the impact of baseline body mass index (BMI) on cardiac reverse remodeling and prognosis following CRT.Methods and Results:A total of 247 CRT patients were included and divided into 4 groups according to baseline BMI. During 6-month follow-up, overweight and obese patients (BMI, 24–28 kg/m2, ≥28 kg/m2, respectively) were inclined to have better clinical and echocardiographic improvements (P<0.05) as well as higher response rate (P<0.001) than underweight and normal weight patients (BMI, <18.5 kg/m2, 18.5–24 kg/m2, respectively). During long-term follow-up, overweight and obese patients had lower all-cause mortality (P=0.015) and combined endpoint of death or HF hospitalizations (P=0.001) than underweight and normal weight patients. Compared with normal weight patients, underweight patients had a 2.29-fold increase in risk of combined endpoint events whereas overweight and obese patients had a reduction in the risk of death (66% and 58%, respectively) and combined endpoint events (52% and 38%, respectively).Conclusions:Patients with obesity and overweight derived more benefit from CRT. Higher BMI was independently associated with better clinical outcome in CRT patients. (Circ J 2014; 78: 2899–2907)