文献一覧: Kazuko Kato (著者)

2 0 0 0 OA Comprehensive Analysis of Lipid Composition in Human Foremilk and Hindmilk

著者: Hiroko Takumi Kazuko Kato Hiroki Nakanishi Maiko Tamura Takayo Ohto-N Saeko Nagao Junko Hirose
出版者: Japan Oil Chemists' Society
雑誌: Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日: pp.ess21449, (Released:2022-06-10)
被引用文献数: 10

Precision nutrition, also referred to as personalized nutrition, focuses on the individual to determine the individual’s most effective eating plan to prevent or treat disease. A precision nutrition for infants requires the determination of the profile of human milk. We compared the lipid profiles of the foremilk (i.e., the initial milk of a breastfeed) and hindmilk (the last milk) of six Japanese subjects and evaluated whether a human milk lipid profile is useful for precision nutrition even though the fat concentration fluctuates during lactation. We detected and quantified 527 species with a lipidome analysis by liquid chromatography-tandem mass spectrometry. The fat concentration in hindmilk (120.6 ± 66.7 μmol/mL) was significantly higher than that in foremilk (68.6 ± 33.3 μmol/mL). While the total carbon number of fatty acids in triglyceride (TG) was highest in C52 for all subjects, the second or third number differed among the subjects. Both the distribution of total carbon number of fatty acids included in TG and the distribution of fatty acids in TG classified by the number of double bonds were almost the same in the foremilk and hindmilk in each subject. The lipids levels containing docosahexaenoic acid and arachidonic acid in total lipids of the foremilk and the hindmilk were almost the same in each subject. Among the sphingolipids and glycerophospholipids, the level of sphingomyelin was the highest in four subjects’ milk, and phosphatidylcholine was the highest in the other two subjects’ milk. The order of their major species was the same in each foremilk and hindmilk. A clustering heatmap revealed the differences between foremilk and hindmilk in the same subject were smaller than the differences among individuals. Our analyses indicate that a human-milk lipid profile reflects individual characteristics and is a worthwhile focus for precision nutrition.

2022-06-13 16:04:45
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2 0 0 0 OA Analysis of Fatty Acid Esters of Hydroxyl Fatty Acid in Nut Oils and Other Plant Oils

著者: Hiroko Takumi Kazuko Kato Takayo Ohto-N. Hiroki Nakanishi Hiroshi Kamasaka Takashi Kuriki
出版者: Japan Oil Chemists' Society
雑誌: Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日: vol.70, no.12, pp.1707-1717, 2021 (Released:2021-12-03)
参考文献数: 25
被引用文献数: 8

Oils and lipids are common food components and efficient sources of energy. Both the quantity and the quality of oils and lipids are important with regard to health and disease. Fatty acid ester of hydroxy fatty acid (FAHFA) is a novel lipid class that was discovered as an endogenous lipid; FAHFAs have shown anti-diabetic effects in a mammalian system. We analyzed the overall FAHFA composition in nut oils and other common oils: almond (raw, roasted), walnut, peanut, olive, palm, soybean, and rapeseed oils. We developed a method of liquid chromatography coupled with electrospray ionization triple quadrupole mass spectrometry (LC-ESI/MS/MS) for a comprehensive target analysis of FAHFAs. The analysis revealed wide variation in the FAHFA profiles (15 compounds and 62 peaks). For 7-11 compounds of FAHFA, a total level of 8-29 pmol/mg oil was detected in nuts oils; for 11 compounds, 4.9 pmol/mg oil was detected in olive oil, and for 4-9 compounds, < 2 pmol/mg oil was detected in palm, soy, and rapeseed oils. The major FAHFAs were FAHFA 36:3, FAHFA 36:2, and FAHFA 36:4 in nut oil, FAHFA 36:2, FAHFA 34:1, and FAHFA 36:1 in olive oil, and FAHFA 32:1, FAHFA 34:0, FAHFA 36:0, and FAHFA 36:1 in all of the common oils. The composition of FAHFAs in nut oils is mainly unsaturated fatty acids, whereas those in olive oil are unsaturated fatty acids and saturated fatty acids. The composition of FAHFAs in common oils was mainly saturated fats. This is the first report to demonstrate the quality and quantity of the FAHFAs in the nut oils. Nuts have been described to be a great source of many nutrients and to be beneficial for our health. Our present findings comprise additional evidence that the intake of nuts in daily diets may prevent metabolic and inflammatory-based diseases.

2021-12-17 10:45:49
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1 0 0 0 OA Comprehensive Analysis of Lipid Composition in Human Foremilk and Hindmilk

著者: Hiroko Takumi Kazuko Kato Hiroki Nakanishi Maiko Tamura Takayo Ohto-N Saeko Nagao Junko Hirose
出版者: Japan Oil Chemists' Society
雑誌: Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日: vol.71, no.7, pp.947-957, 2022 (Released:2022-07-01)
参考文献数: 36
被引用文献数: 10

2022-07-07 23:57:06
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1 0 0 0 OA Impact of CYP2D6*10 polymorphism on the pharmacokinetics of mirtazapine and its desmethylated metabolite in Japanese psychiatric patients treated with mirtazapine

著者: Takashi Watanabe Yuki Hayashi Akiko Aoki Shin Ishiguro Mikito Ueda Kazufumi Akiyama Kazuko Kato Yoshimasa Inoue Shoko Tsuchimine Norio Yasui-Furukori Kazutaka Shimoda
出版者: 日本臨床精神神経薬理学会
雑誌: Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)
巻号頁・発行日: vol.6, pp.5-15, 2015 (Released:2015-03-13)
参考文献数: 39

Purpose: This study evaluated the impact of CYP2D6 polymorphism, and particularly CYP2D6*10 alleles, on the steady-state plasma concentrations of mirtazapine (MIR) and its metabolite N-desmethylmirtazapine (DMIR) in Japanese psychiatric patients.Patients and Methods: The subjects were 75 Japanese patients treated with racemic MIR. The steady-state plasma concentrations of MIR and DMIR were measured using liquid chromatography. The CYP2D6 genotypes were determined by polymerase chain reaction. Three subjects whose plasma levels of MIR and DMIR were below the limit of detection were regarded as non-adherent and excluded, and 4 subjects having the CYP2D6*5 allele (CYP2D6*1/CYP2D6*5 and CYP2D6*2/CYP2D6*5 (n = 3) and CYP2D6*5/CYP2D6*10 (n = 1)) were excluded from the analysis in order to eliminate the effect of the CYP2D6*5 allele. Accordingly, data from 68 subjects were subjected to analysis.Results: There were no significant differences in the plasma concentrations of MIR or DMIR (all corrected for dose and body weight) among different CYP2D6 genotypes. Multiple regression analysis also revealed that age affects MIR (corrected for dose and body weight) (p=0.079). Also, multiple regression analysis revealed that age correlated significantly to the plasma concentration of DMIR (corrected for dose and body weight) (p=0.026). Neither sex nor the number of CYP2D6*10 alleles were significant factors for either the plasma concentration of MIR (corrected for dose and body weight) or the plasma concentration of DMIR (corrected for dose and body weight).Conclusion: CYP2D6*10 polymorphism did not significantly affect the steady-state plasma levels of MIR and DMIR in Japanese patients, but age had a significant effect on the plasma levels of DMIR.

2015-03-13 12:39:53
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