著者

Kensuke NAKAJIMA Eizi TOYODA Masaki ISHIWATARI Shin-ichi TAKEHIRO Yoshi-Yuki HAYASHI

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.82, no.6, pp.1483-1504, 2004 (Released:2005-03-02)

参考文献数

23

被引用文献数

6 9 7

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For the purpose of examining the initial development of the atmospheric response to a warm SST anomaly placed at the equator, an ensemble switch-on experiment is conducted with an aqua-planet GCM. An ensemble average of the size of 128 significantly reduces the transient noises caused by both small scale convective activity and large scale intraseasonal variability.In the first three days after the switch-on of the SST anomaly, a convection center develops above the warm SST area. As a barotropic response to the heating of convection center, a global increase of surface pressure occurs outside the low pressure region around the warm SST area. The response after the emergence of the high pressure anomaly is consistent with Gill (1980); a warm Kelvin wave-like anomaly is emitted to the east of the convection center, while a warm Rossby wave-like anomaly is emitted to the west.The Kelvin wave-like signal propagates at a speed slower than that of free Kelvin wave expected from its vertical wavelength, suggesting that the signal is a “moist” Kelvin wave. Transient decrease of precipitation occurs at the moist Kelvin wave front; a decrease of convection associated with the downward motion at the wave front is consistent with its slow propagation. After several days, precipitation recovers and is even intensified because of the surface frictional convergence associated with the Kelvin wave-like equatorial low pressure anomaly. To the west of the warm SST area, on the other hand, precipitation decreases monotonically. The continuous reduction of precipitation is caused by the equatorial surface frictional divergence associated with the relatively high pressure anomaly at the equator of the Rossby wave structure.Finally, there appears a slow zonally symmetric response within the Hadley cell characterized with surface pressure rise in the tropics and westerly wind anomaly in the troposphere. The change of eddy zonal momentum transport, together with the transport toward the lower level by the Hadley circulation and the geostrophic adjustment to the resulting low level westerly acceleration, seems to be responsible for the response.

著者

Takashi Watanabe Yuki Hayashi Akiko Aoki Shin Ishiguro Mikito Ueda Kazufumi Akiyama Kazuko Kato Yoshimasa Inoue Shoko Tsuchimine Norio Yasui-Furukori Kazutaka Shimoda

出版者

日本臨床精神神経薬理学会

雑誌

Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)

巻号頁・発行日

vol.6, pp.5-15, 2015 (Released:2015-03-13)

参考文献数

39

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Purpose: This study evaluated the impact of CYP2D6 polymorphism, and particularly CYP2D6*10 alleles, on the steady-state plasma concentrations of mirtazapine (MIR) and its metabolite N-desmethylmirtazapine (DMIR) in Japanese psychiatric patients.Patients and Methods: The subjects were 75 Japanese patients treated with racemic MIR. The steady-state plasma concentrations of MIR and DMIR were measured using liquid chromatography. The CYP2D6 genotypes were determined by polymerase chain reaction. Three subjects whose plasma levels of MIR and DMIR were below the limit of detection were regarded as non-adherent and excluded, and 4 subjects having the CYP2D6*5 allele (CYP2D6*1/CYP2D6*5 and CYP2D6*2/CYP2D6*5 (n = 3) and CYP2D6*5/CYP2D6*10 (n = 1)) were excluded from the analysis in order to eliminate the effect of the CYP2D6*5 allele. Accordingly, data from 68 subjects were subjected to analysis.Results: There were no significant differences in the plasma concentrations of MIR or DMIR (all corrected for dose and body weight) among different CYP2D6 genotypes. Multiple regression analysis also revealed that age affects MIR (corrected for dose and body weight) (p=0.079). Also, multiple regression analysis revealed that age correlated significantly to the plasma concentration of DMIR (corrected for dose and body weight) (p=0.026). Neither sex nor the number of CYP2D6*10 alleles were significant factors for either the plasma concentration of MIR (corrected for dose and body weight) or the plasma concentration of DMIR (corrected for dose and body weight).Conclusion: CYP2D6*10 polymorphism did not significantly affect the steady-state plasma levels of MIR and DMIR in Japanese patients, but age had a significant effect on the plasma levels of DMIR.