著者
Yoshiaki Kaneko Tadashi Nakajima Akihiko Nogami Yasuya Inden Tetsuya Asakawa Itsuro Morishima Akira Mizukami Takashi Iizuka Shuntaro Tamura Chihiro Ota Yasunori Kanzaki Kazuya Nakagawa Makoto Suzuki Masahiko Kurabayashi
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.1, no.2, pp.46-54, 2019-02-08 (Released:2019-02-08)
参考文献数
40
被引用文献数
4 4

Background: The existence of atypical fast-slow (F/S) atrioventricular (AV) nodal reentrant tachycardias (NRT) using slow pathway (SP) variants connected to the right atrial (RA) inferolateral (inf) free wall (FW) along the tricuspid annulus (TA), has been neither confirmed nor precisely characterized. Methods and Results: We studied 7 patients (mean age, 48±16 years; 5 men) with F/S-AVNRT with long RP intervals and an earliest atrial activation at the RA inf-FW along the TA (inf-F/S-AVNRT). AV reentrant tachycardia was excluded on observation of the transition zone criteria in all 7 patients. Atrial tachycardia was excluded on the observation of a V-A-V activation sequence after the induction or entrainment of the tachycardia from the right ventricle in all. During the tachycardia, low-frequency, fractionated potentials (LP) preceding the local atrial electrogram were recorded near the site of the earliest atrial activation in 6 patients. Observations of conduction delay and block of the LP during ventricular entrainment or ablation of the tachycardia indicated that LP reflect retrograde activation via the inf-SP. Retrograde SP conduction was interrupted at the site of earliest atrial activation in 3 patients, and in the right posterior septum in 4 patients. Conclusions: inf-F/S-AVNRT are distinct supraventricular tachycardia incorporating an SP variant connected to the RA inf-FW along the TA in the retrograde direction, which were eliminated by ablation.
著者
Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
出版者
一般社団法人日本機械学会
雑誌
Mechanical Engineering Journal (ISSN:21879745)
巻号頁・発行日
vol.2, no.3, pp.15-00063-15-00063, 2015 (Released:2015-06-15)
参考文献数
61
被引用文献数
1 6

In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.
著者
Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
出版者
一般社団法人日本機械学会
雑誌
Mechanical Engineering Journal (ISSN:21879745)
巻号頁・発行日
pp.15-00063, (Released:2015-05-22)
参考文献数
61
被引用文献数
1 6

In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.