著者

Shinichi Suzuki Shunichi Yamashita Toshihiko Fukushima Keiichi Nakano Sanae Midorikawa Akira Ohtsuru Seiji Yasumura Mitsunori Hosoya Kenji Kamiya Hiroki Shimura Satoru Suzuki Izumi Nakamura Masafumi Abe

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ15-0726, (Released:2016-02-27)

被引用文献数

3 37

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After the Fukushima nuclear power plant accident on March 11, 2011, the public of Japan became particularly concerned about the possibility of an increased risk of childhood thyroid cancer, similar to what was observed after the Chernobyl’s accident. Due to serious public health perception, there was an urgency to evaluate the baseline levels of childhood thyroid status in Fukushima prefecture. Therefore we have commenced a thyroid ultrasound examination (TUE) survey of the approximately 360,000 pediatric inhabitants (0 to 18 years of age) who lived in Fukushima at the time of the accident in October 2011. The subjects were divided into three categories according to the standardized diagnostic criteria of ultrasound findings. Category A contained the subjects whose TUE findings were intact or benign. Category B were recommended a confirmatory TUE. Category C was recommended an immediate confirmatory TUE. Results: The survey of 40,302 subjects in the first year was completed in March, 2013. There were 40,097 (99.5%), 205 (0.50%) and 0 subjects in categories A, B and C, respectively. Of the 82 category B subjects who underwent FNAC, 12 were diagnosed with a malignant tumor or were suspected to have malignancy. The 12 subjects received thyroid surgery and 11 thyroid cancers and one benign nodule were confirmed histologically after surgery. This is the first large-scaled TUE survey to employ sophisticated ultrasound screening and aim to evaluate the baseline frequency of childhood thyroid nodules and cysts. The results will become the golden standard of future comparative TUE in Fukushima, Japan.

著者

Shinichi Suzuki Shunichi Yamashita Toshihiko Fukushima Keiichi Nakano Sanae Midorikawa Akira Ohtsuru Seiji Yasumura Mitsunori Hosoya Kenji Kamiya Hiroki Shimura Satoru Suzuki Izumi Nakamura Masafumi Abe

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.63, no.3, pp.315-321, 2016 (Released:2016-03-31)

参考文献数

15

被引用文献数

3 37

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After the Fukushima nuclear power plant accident on March 11, 2011, the public of Japan became particularly concerned about the possibility of an increased risk of childhood thyroid cancer, similar to what was observed after the Chernobyl’s accident. Due to serious public health perception, there was an urgency to evaluate the baseline levels of childhood thyroid status in Fukushima prefecture. Therefore we have commenced a thyroid ultrasound examination (TUE) survey of the approximately 360,000 pediatric inhabitants (0 to 18 years of age) who lived in Fukushima at the time of the accident in October 2011. The subjects were divided into three categories according to the standardized diagnostic criteria of ultrasound findings. Category A contained the subjects whose TUE findings were intact or benign. Category B were recommended a confirmatory TUE. Category C was recommended an immediate confirmatory TUE. Results: The survey of 40,302 subjects in the first year was completed in March, 2013. There were 40,097 (99.5%), 205 (0.50%) and 0 subjects in categories A, B and C, respectively. Of the 82 category B subjects who underwent fine needle aspiration cytology (FNAC), 12 were diagnosed with a malignant tumor or were suspected to have malignancy. The 12 subjects received thyroid surgery and 11 thyroid cancers and one benign nodule were confirmed histologically after surgery. This is the first large-scaled TUE survey to employ sophisticated ultrasound screening and aim to evaluate the baseline frequency of childhood thyroid nodules and cysts. The results will become the golden standard of future comparative TUE in Fukushima, Japan.

著者

Tatsuo Shimura Masahiko Shibata Kenji Gonda Takahiro Nakajima Shun Chida Masaru Noda Satoshi Suzuki Izumi Nakamura Keiichi Nakano Toshihiko Fukushima Shinichi Suzuki Seiichi Takenoshita

出版者

日本癌病態治療研究会

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.24, no.1, pp.35-40, 2016-01-13 (Released:2016-03-31)

参考文献数

40

被引用文献数

2

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Background and Aims: Several investigators have reported the significance of circulating galectin-3 in thyroid cancer patients. However, the precise meaning of circulating galectin-3 remains unclear. The aim of this study was to investigate the relationships between serum galectin-3 levels and angiogenetic factors, and nutritional and inflammatory indicators in patients with thyroid cancer. Materials and Methods: Sixty-one patients with thyroid tumors were enrolled, comprising 47 pre-treatment thyroid cancer patients and 14 patients with benign thyroid diseases. Galectin-3, interleukin (IL)-6, vascular endothelial growth factor, granulocyte colony-stimulating factor (G-CSF), soluble form of intercellular adhesion molecule-1 (sICAM-1), retinol binding protein, prealbumin, albumin, and transferrin were measured. C-reactive protein (CRP), neutrophil count, lymphocyte count, and neutrophil/lymphocyte ratio (NLR) were also investigated. Results: The amounts of circulating galectin-3 in benign disease and thyroid cancer were significantly higher than those of healthy volunteers (P < 0.001). Analysis of galectin-3 performance in distinguishing malignant disease from benign disease using a receiver operating characteristic curve revealed that the area under the curve was 0.555. There were statistically significant correlations between the circulating amount of galectin-3 and IL6, G-CSF, and sICAM-1. Serum galectin-3 showed statistically significant correlations with albumin, prealbumin, and transferrin. Circulating galectin-3 exhibited strong correlations with CRP, neutrophil count, lymphocyte count, and NLR. Conclusions: Galectin-3 may be one of the key factors in the regulation of angiogenesis, inflammation, and nutrition.

著者

中野 敬一 Keiichi NAKANO

雑誌

女性学評論 = Women's Studies Forum

巻号頁・発行日

vol.28, pp.47-67, 2014-03

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本論では聖書において「売春女性」がどう扱われているかを確認した。まず旧約聖書では「神殿娼婦」と「遊女」が登場する。神殿娼婦は異教の習慣であり、イスラエルの聖所においては厳しく禁じられていた(例:申命記23:18)。しかし実際にはイスラエルにおいても神殿娼婦との淫行がみられ、預言者は神の審判を予言したのである。(例 : ホセア記4:14)。一方、遊女に対しては神殿娼婦ほどの避難はなされていない。新約聖書には、旧約聖書における「遊女」の同義語である「娼婦」が登場する。彼女たちの社会的地位は低く、特に律法学者やファリサイ派などのユダヤ教指導者層から差別されていた。しかしイエスは「徴税人や娼婦たちの方が、あなたたちより先に神の国に入るだろう」(マタイ福音書21:31)と述べた。また「罪深い女」(ルカ 7:36)と呼ばれていた娼婦を受け入れた。イエスは彼女たちを救いに招いたのである。しかし、後のキリスト者やキリスト教会はイエスの姿勢を継承しなかったと言える。例えば、パウロはコリント教会における淫行を禁じ、そのような行いをなす人々を排除するよう命じた。彼はキリスト者が娼婦と一体となることを戒めており、「みだらな者は神の国を受け継ぐことができない」と述べた(Ⅰコリント 6:10)。パウロらの思想は後のキリスト教会に受け継がれた。教父時代においては禁欲が重視され、売春女性は教会から排除された。しかし、同時に「必要悪」として認められた。さらにこのような傾向は中世ヨーロッパのキリスト教会にも継続され、社会や教会の純潔が守られるために、売春は是認されるのである。宗教改革者たちも売春女性を厳しく差別したが、カトリック教会と同様「必要悪」として彼女たちを容認したのである。 In this paper, I explored how prostitutes are treated in the Bible. "Shrine prostitute" and "harlot" appear in the Old Testament. The shrine prostitute was a custom of paganism and was forbidden in Israeli holy places (ex. Deuteronomy 23:18). In fact, however, immoral sexual acts with shrine prostitutes were observed in Israel, and the prophets foretold the judgement of God (ex. Hosea 4:14). On the other hand, Israelis did not criticize harlots as shrine prostitutes. "Prostitute", which is a synonym of "harlot", appears in the New Testament. Their social status was low; they were discriminated against by the class of Jewish leaders such as the scribes and the Pharisees. However, Jesus said to them, "the tax collectors and the prostitutes are going into the kingdom of God ahead of you" (Matthew 21:31 ). In addition, he accepted "a sinful woman" (Luke 7:36 ) who was a prostitute. Jesus invited her to salvation. However, it may be said that the later Christian church and heritage did not follow this position of Jesus. For example, the apostle Paul forbade sexual immorality in the Corinth church and commanded that it remove people who performed such an act. Paul banned a Christian and a prostitute from becoming one body and stated, "fornicators will not inherit the kingdom of God" (I Corinthians 6:10). The thoughts of Paul were inherited by the later Christian churches. Abstinence was made much of in the Church Father era, and prostitutes were removed from churches. However, it was recognized as "a necessary evil" at the same time. Furthermore, this tendency continued in the Catholic Church of the Middle Ages, and the church approved prostitution to protect the purity of society and the church. Religious reformers also discriminated harshly against prostitutes, but accepted them as "a necessary evil" in the same way as the Catholic Church.

著者

中野 敬一 Keiichi NAKANO

雑誌

神戸女学院大学論集 = KOBE COLLEGE STUDIES

巻号頁・発行日

vol.59, no.2, pp.103-120, 2012-12-20

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Chiristianity was first introduced into Japan in 1549 by the Catholic missionary, Francis Xavier. However, Christians were persecuted quite strongly by the ruling forces of the time. By the mid 17th centuty, missionary work conducted in public had completely ceased to exist. Christianity was re-introduced into Japan in 1859. In the Meiji era various sects of Protestant and Catholic missionary groups from various contries, particularly from the United States, arrived in Japan once again and started their missionaty work. Missionaty groups introduced Japanese to Christian ideas of the other world (afterworld, the world beyond) and Japanese who became Christian believed what the missonaries taught. What kinds of ideas have Japanese accepted and developed? To know the ideas of the other world of Japanese converts in the Meiji era, we study sermons and articles by famous Japanese preachers (such as Jo Niijima, Masahisa Uemura, Kanzo Uchimura and so on), tracts written by missionaries, and hymns that Christians in Japan used in the Meiji era. Studying these materials, we could see some common characteristics of the ideas of the other world. The preachers or missinaries insist that there is a "Heaven" with God. In heaven, the deceased have peace and happiness, and can meet Got and the other dead who already were there. In particular, "to meet again" with family members or friends are significant words for hope in Heaven. The Japanese Christians who believed these ideas must have been comforted and given hope for their future. The important thing that we have to comfirm is that we could not see any specific image of Heaven or Hell. For example, they ded not talk about the form or shape of Heaven, or the condeition of the deceased.

著者

中野 敬一 Keiichi NAKANO

出版者

神戸女学院大学女性学インスティチュート

雑誌

女性学評論 = Women's studies forum (ISSN:09136630)

巻号頁・発行日

no.31, pp.227-249, 2017-03

著者

Yuuki TAKAMURA Keiichi NAKANO Takashi URUNO Yasuhiro ITO Akihiro MIYA Kaoru KOBAYASHI Tamotsu YOKOZAWA Fumio MATSUZUKA Kanji KUMA Akira MIYAUCHI

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.50, no.5, pp.595-601, 2003 (Released:2003-11-12)

参考文献数

39

被引用文献数

15 30

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TSH receptor antibodies (TRAb) are generally regarded as mediators of thyroid stimulation in Graves' disease. In addition, a high serum TRAb value during pregnancy is one of the risk factors for intrauterine death, prematurity, and fetal or neonatal hyperthyroidism. Recently, correlations between a high serum TRAb value and endocrine opthalmopathy were also suggested. Surgical resection of the thyroid is usually followed by a reduction of serum TRAb levels in variable degrees. The relation between the extent of the thyroidectomy and the degree of reduction is still controversial. In addition, the changes in the TRAb value after total thyroidectomy (TT) over a long period of time have never been studied. We studied the changes in serum TRAb values after TT and subtotal thyroidectomy (ST) for more than 7 years. Forty-one patients with Graves' disease underwent TT, and 99 patients underwent ST. The serum TRAb values and the ratio of the patients who achieved normal values among each group (normalization rates of TRAb) at 3 and 6 months, 1, 3, 5 and 7 years after surgery were compared between the TT group and ST group. The mean preoperative TRAb values were not significantly different between the TT and ST groups, and the mean TRAb values measured 3, 6 and 12 months after surgery were not significantly different between the groups. However, the TRAb values measured 3, 5 and 7 years after surgery were significantly (p