著者
Tatsuo Shimura Masahiko Shibata Kenji Gonda Takahiro Nakajima Shun Chida Masaru Noda Satoshi Suzuki Izumi Nakamura Keiichi Nakano Toshihiko Fukushima Shinichi Suzuki Seiichi Takenoshita
出版者
日本癌病態治療研究会
雑誌
Annals of Cancer Research and Therapy (ISSN:13446835)
巻号頁・発行日
vol.24, no.1, pp.35-40, 2016-01-13 (Released:2016-03-31)
参考文献数
40
被引用文献数
1

Background and Aims: Several investigators have reported the significance of circulating galectin-3 in thyroid cancer patients. However, the precise meaning of circulating galectin-3 remains unclear. The aim of this study was to investigate the relationships between serum galectin-3 levels and angiogenetic factors, and nutritional and inflammatory indicators in patients with thyroid cancer. Materials and Methods: Sixty-one patients with thyroid tumors were enrolled, comprising 47 pre-treatment thyroid cancer patients and 14 patients with benign thyroid diseases. Galectin-3, interleukin (IL)-6, vascular endothelial growth factor, granulocyte colony-stimulating factor (G-CSF), soluble form of intercellular adhesion molecule-1 (sICAM-1), retinol binding protein, prealbumin, albumin, and transferrin were measured. C-reactive protein (CRP), neutrophil count, lymphocyte count, and neutrophil/lymphocyte ratio (NLR) were also investigated. Results: The amounts of circulating galectin-3 in benign disease and thyroid cancer were significantly higher than those of healthy volunteers (P < 0.001). Analysis of galectin-3 performance in distinguishing malignant disease from benign disease using a receiver operating characteristic curve revealed that the area under the curve was 0.555. There were statistically significant correlations between the circulating amount of galectin-3 and IL6, G-CSF, and sICAM-1. Serum galectin-3 showed statistically significant correlations with albumin, prealbumin, and transferrin. Circulating galectin-3 exhibited strong correlations with CRP, neutrophil count, lymphocyte count, and NLR. Conclusions: Galectin-3 may be one of the key factors in the regulation of angiogenesis, inflammation, and nutrition.
著者
Ammar Ebrahimi Pejman Abbasi Magali Cucchiarini
出版者
The Japanese Society of Strategies for Cancer Research and Therapy
雑誌
Annals of Cancer Research and Therapy (ISSN:13446835)
巻号頁・発行日
vol.28, no.1, pp.3-8, 2020-01-21 (Released:2020-01-21)
参考文献数
54

Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.
著者
Mohammad Al Sorkhy Zina Fahl Jenna Ritchie
出版者
The Japanese Society of Strategies for Cancer Research and Therapy
雑誌
Annals of Cancer Research and Therapy (ISSN:13446835)
巻号頁・発行日
vol.26, no.1, pp.19-25, 2048-01-16 (Released:2018-03-27)
参考文献数
46

Breast cancer (BC) is a commonly diagnosed cancer amongst women and the second leading cause of cancer deaths in the world. BC has created huge challenges to healthcare providers regarding the identification of main risk factors and how they contribute to the development of the disease. Several studies suggest that biological risk factors such as duration of breast feeding, age at menarche, menopausal status and the use of contraceptive pills have contributed to the increase of BC diagnoses. Moreover, psychological factors such as depression, stress and negative lifestyles are gaining more attention as a major contributor to this type of cancer. The role of psychological stress regarding BC has been widely demonstrated in the literature across several fields including but not exclusive to epidemiology, physiology, and molecular biology which all show a clear relationship between intracellular stress signaling and protumorigenic pathways within breast cells. Cortisol is primary stress hormone of the human body and a growing body of research both clinically and molecularly are revealing a positive correlation of high cortisol levels and the progression of BC. This review attempts to establish and highlight how cortisol levels impact breast cancer development and progression.
著者
Hisanori Shoji Masahiko Motegi Kiyotaka Osawa Noriyuki Okonogi Atsushi Okazaki Yoshitaka Andou Takayuki Asao Hiroyuki Kuwano Takeo Takahashi Kyoji Ogoshi
出版者
The Japanese Society of Strategies for Cancer Research and Therapy
雑誌
Annals of Cancer Research and Therapy (ISSN:13446835)
巻号頁・発行日
vol.22, no.1, pp.28-35, 2014-06-27 (Released:2014-12-19)
参考文献数
30
被引用文献数
1 7

Background: Hyperthermia has not been approved as a standard treatment method in oncology. One of the major problems is that there is no reference point for this therapy. Another problem is that radiofrequency hyperthermia has a fatal flaw, the hot spot phenomenon, which does not allow continuation of treatment without lowering the output. Patients and Methods: Hyperthermia treatment was administered either alone or concomitantly with chemotherapy and/or radiotherapy to 76 consecutive patients with malignancies, using Thermotron RF-8, between December 2011 and April 2014. Radiofrequency hyperthermia was administered 5 times for 5 weeks with 50 min irradiation in all patients. Results: Complete response (CR) was seen in 35.2% of primary cases, but in 4.5% of recurrent cases, and this rate was higher in patients with three days after first chemoradiation. There was significant correlation among the initial irradiation output at which complications occurred, initial time at which complications occurred and the physical status of the patients, such as visceral fat area. All patients with CR had significantly higher increased body temperature than the other patients. However, patients with progressive disease and 17 or more Hidaka output points showed significantly higher increased body temperature than patients with partial response or stable disease. Conclusions: Patients with CR had higher temperatures, but some patients with higher temperature also showed progressive disease. Further studies to examine the discrepancy between the clinical and histological response by using a large sample of surgically resected cases and to validate and reconfirm our findings are warranted.