著者

Takahisa Ogawa Hiroto Hayashi Toshiki Kishimoto Shota Mashimo Yasuaki Kusumoto Keisuke Nakamura Takuya Aoki Janelle Moross Morten Tange Kristensen Hideaki Ishibashi

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.5, pp.20200030, 2020 (Released:2020-12-02)

参考文献数

36

被引用文献数

1 5

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Objectives: The aim of this study was to translate the Cumulated Ambulation Score (CAS) from English into Japanese in cooperation with different types of healthcare providers and to investigate its inter-rater reliability and internal consistency.Methods: Two physical therapists at each of three general hospitals in Japan measured the mobility of 50 consecutive post-operative hip fracture patients on two occasions between 2 and 6 days after surgery using the Japanese version of the CAS (CAS-JP). We analyzed the inter-rater reliability and agreement using both the linear weighted kappa and the interclass correlation coefficient; we also analyzed the internal consistency using Cronbach’s alpha coefficient.Results: The mean age of patients was 81 (SD: 11.6) years and 82% were women. Approximately half of the patients had severe cognitive impairment. Kappa was ≥ 0.93 for the three mobility activities and for the total CAS-JP score, the percentage agreement was ≥ 0.98, the ICC was ≥ 0.95, and Cronbach’s alpha coefficient was 0.85.Conclusions: We found that the CAS-JP possessed good inter-rater reliability, agreement, and internal consistency. The CAS-JP is a reliable and easy-to-use evaluation tool suitable for daily clinical practice across different healthcare providers to monitor mobility in older hip fracture patients in Japan. We suggest that CAS-JP be evaluated in future studies for use in younger patients and in other patient groups with mobility problems.

著者

Takamitsu Otake Keisuke Nakamura Nobuyasu Hanari

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.48, no.4, pp.137-148, 2023-11-20 (Released:2023-12-08)

参考文献数

57

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A method of quantifying glyphosate (Gly) in human urine by means of MonoSpin TiO extraction and 9-fluorenylmethoxycarbonyl chloride (FMOC-Cl) derivatization with isotope dilution mass spectrometry (IDMS) was investigated and optimized. The method’s quantification limit under optimized conditions was 0.3 µg/kg for FMOC-Gly, which was comparable to or lower than those described in previous studies. When a spike test using human urine samples was carried out with optimized analytical conditions, the trueness for FMOC-Gly was as follows: 101.6–104.9% for a spike level of 0.5 µg/kg and 99.2–101.0% for a spike level of 30 µg/kg. The intra-day repeatability and inter-day reproducibility were <6.5%. The spike test results for validation between the “with” and “without” derivatization methods were comparable at 1 µg/kg. Our results indicate that using MonoSpin TiO extraction and FMOC-Cl derivatization with IDMS is an accurate method for analyzing Gly in human urine.

著者

Hiroki Iwata Keisuke Nakamura Noriko Kobayashi Kazuko Fujimoto Naoko Hayashi Katsunori Yamaura

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

pp.2022.01091, (Released:2022-12-19)

参考文献数

11

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Community pharmacies are required to play a role in maintaining the health of local residents. Since September 2015, a national policy in Japan has allowed saliva tests to be used for oral health check-ups at community pharmacies. In the present study, we aimed to reveal dentists' perceptions and expectations for oral health check-ups provided at community pharmacies. A questionnaire survey was administered to dentists at 1,000 randomly selected dental clinics in Tokyo, Japan; 257 responses (25.7%) were included in the analysis and 85.2% of respondents approved of oral health check-ups at community pharmacies. Most respondents who approved of oral health check-ups expected that community pharmacists would recommend that local residents visit a dental clinic (85.8%) and provide a report to dentists (60.3%) after the check-up. Furthermore, 79.0% of respondents desired collaboration with community pharmacies. These findings suggested the potential for oral health check-ups to facilitate collaboration between community pharmacies and dental clinics aimed at maintaining and improving oral health of local residents.

著者

Keisuke Nakamura Masayoshi Ohira Yoshiharu Yokokawa

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.10, pp.1631-1633, 2014 (Released:2014-10-28)

参考文献数

15

被引用文献数

1 6

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[Purpose] The aim of this study was to investigate the steady state of oxygen uptake (VO2) at several standing up frequencies to clarify whether workload in the sit-to-stand exercise (STSE) is greater than the anaerobic threshold (AT). [Subjects] Ten healthy young subjects performed the STSE. [Methods] In the STSE, subjects stood up and sat down without using their arms to push-off from the chair at standing up frequencies of 6, 12, 18, 24, 30, and 36 times per minutes. Subjects exercised for 5 minutes at each frequency with 5 minutes of rest between each consecutive frequency trial. The steady state of VO2 was evaluated by the difference in the VO2 between the 3rd and 5th min at each frequency. The correlation between the VO2 of the STSE and the standing up frequency was analyzed. [Results] At standing up frequencies greater than 24 times/min, the steady state of VO2 could not be confirmed. The relationship between the standing up frequency (at less than 24 times/min) and VO2 was strong (r=0.94). [Conclusion] The STSE may be a potentially useful test for determining AT and predicting the physical capacity of patients.

著者

Koji FUKUI Keisuke NAKAMURA Masashi SHIRAI Anna HIRANO Hirokatsu TAKATSU Shiro URANO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.61, no.5, pp.362-368, 2015 (Released:2015-12-04)

参考文献数

30

被引用文献数

3 19

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Vitamin E inhibits oxidative processes in living tissues. We produced vitamin E-deficient mice by feeding them a vitamin E-deficient diet to verify the influence of chronic vitamin E deficiency on cognitive function. We measured cognitive function over a 5-d period using the Morris water maze task, as well as antioxidant enzyme activity and lipid peroxidation in discrete brain regions, and total serum cholesterol content. Three- and six-mo-old vitamin E-deficient and age-matched control mice were used. In addition, 24-mo-old mice were used as an aged-model. In the 3-mo-old mice, cognitive function in the vitamin E-deficient (short-term vitamin E-deficient) group was significantly impaired compared to age-matched controls. Although the lipid peroxidation products in the cerebral cortex, cerebellum and hippocampus did not significantly differ in 3-mo-old mice, the levels in the 6-mo-old vitamin E-deficient (long-term vitamin E-deficient) mice were significantly increased compared to age-matched controls. Serum cholesterol content was also significantly increased in the short- and long-term vitamin E-deficient mice compared to their respective age-matched controls. These results indicate that chronic vitamin E deficiency may slowly accelerate brain oxidation. Thus, vitamin E concentrations may need to be monitored in order to prevent the risk of cognitive dysfunction, even under normal conditions.