著者

Masaki Hayakawa Keisuke Takano Michinori Kayashima Kei Kasahara Hidetada Fukushima Masanori Matsumoto

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.58362, (Released:2020-10-28)

参考文献数

30

被引用文献数

17

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Patients with severe COVID-19 often experience complications including coagulopathy and fatal thrombosis. COVID-19 pneumonia sometimes leads to acute respiratory distress syndrome, requiring extracorporeal membrane oxygenation (ECMO), during which thrombosis and bleeding are major causes of death. Anticoagulation such as heparin is essential for COVID-19 patients on ECMO; however, bleeding might be caused by not only heparin, but also acquired von Willebrand syndrome (AVWS). To date, no study has examined ECMO-related bleeding and AVWS in COVID-19 patients.We report a COVID-19 patient who experienced bleeding from AVWS in addition to disseminated intravascular coagulation (DIC) during ECMO. The level of high–molecular weight VWF multimers decreased during ECMO therapy, and these findings promptly improved after discontinuation of ECMO. Plasma levels of VWF antigen were extremely high, probably due to endothelial cell damage caused by COVID-19. On the other hand, plasma levels of ADAMTS13 activity were moderately reduced, to 20–30% of normal. The patient was successfully treated with cryoprecipitate in bleeding during ECMO without a reduction in heparin, which might have induced thromboembolism. Bleeding found in this patient might be caused by AVWS and DIC.Severe COVID-19 patients are in a thrombotic state and need to receive anticoagulant therapy. However, once they receive ECMO therapy, bleeding symptoms could be observed. In such cases, physicians should think of AVWS in addition to the side effect of heparin and DIC.

著者

Alima DORZHIEVA Makoto NAKATA Keisuke TAKANO Youki FUJIHIKO Yasuo ITO Kiyoshi AKAHARA Katsuyoshi TACHIKAWA Yasuko ICHIMURA Yaeko FURUKAWA Hiroshi SATO Mikiko FUJISAWA Mika OKAMOTO Takehiko SHIMIZU

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.19, no.1, pp.41-53, 2020 (Released:2020-01-30)

参考文献数

45

被引用文献数

2

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Changes in the timing of bird migration in spring and autumn in a coastal forest near the city of Niigata, central Honshu, Japan, were analyzed based on 27 years of bird-banding records. Half of the bird species studied, including all migratory types except residents, arrived or departed significantly earlier in spring due to an increase in spring temperatures. The rate of change we observed in spring migration timing due to changes in temperature was identical to or slightly greater than those reported in studies from other countries. The spring arrival of the Narcissus Flycatcher Ficedula narcissina and the Japanese Thrush Turdus cardis, both long-distance summer migrants to the nearby mountains, became earlier (advanced), however, for reasons that remained unclear. Median capture date in autumn was significantly associated with year for five species. Of these, the median capture date of the Japanese White-eye Zosterops japonicus, a resident and wandering bird, and the Black-faced Bunting Emberiza spodocephala, a wandering bird, advanced annually, while for the Japanese Robin Luscinia akahige and two other species (all long-distance migrants), it was delayed. We hypothesize that forest succession from a simple pine forest to a mixed forest with well-developed sub-canopy and shrub layers may have strongly influenced the Japanese White-eye and the Black-faced Bunting due to changes in population structure in the study area, resulting in an earlier median autumn capture date. Forest succession may also have influenced the Japanese Robin's food resources, enabling it to stay longer in the study area and resulting in a delay in autumn departure date. Thus, changes in bird migration timing differ according to different environmental factors in spring and autumn.

著者

Hiroshi Furuta Adam Pander Keisuke Takano Hiroki Miyaji Akimitsu Hatta Makoto Nakajima

出版者

応用物理学会

雑誌

2017年第78回応用物理学会秋季学術講演会

巻号頁・発行日

2017-07-21