著者

Yoshinori FURUKAWA Ken NAGASHIMA Etsuro YOKOYAMA Shunichi NAKATSUBO Salvador ZEPEDA Izumi YOSHIZAKI Haruka TAMARU Taro SHIMAOKA Takehiko SONE Takao MAKI Asuka YAMAMOTO Toshiyuki TOMOBE Ken-ichiro MURATA Gen SAZAKI

出版者

The Japan Society of Microgravity Application

雑誌

International Journal of Microgravity Science and Application (ISSN:21889783)

巻号頁・発行日

vol.38, no.1, pp.380101, 2021 (Released:2021-01-31)

参考文献数

53

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Microgravity experiments on ice crystal growth in supercooled water without any effect of convection flow were carried out twice in Kibo of the International Space Station as projects called “Ice Crystal 1” and “Ice Crystal 2”. Many video movies recording the growth process of a single ice crystal were analyzed to clarify the pattern formation processes of single ice crystals and the impurity effect on ice crystal growth kinetics. In the Ice Crystal 1 project, ice crystals were grown in supercooled pure D2O and the pattern formation mechanism for the ice crystal was clarified on the basis of crystal plane-dependent growth kinetics between the basal face and the other crystallographic faces. In the Ice Crystal 2 project, ice crystals were grown in supercooled H2O containing a small amount of an antifreeze glycoprotein as an impurity. Growth enhancement and oscillation for the basal faces were observed for the first time, and their mechanisms were clarified on the basis of the crystal plane-dependent impurity effect of an antifreeze glycoprotein. The origin of the antifreeze function of antifreeze glycoproteins was ultimately explained in connection with the basic criterion for the pattern formation of a polyhedral crystal.

著者

Kozo Yao Ken Nagashima Hiroyuki Miki

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.100, no.4, pp.243-261, 2006 (Released:2006-04-18)

参考文献数

135

被引用文献数

37 70

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Benidipine is a dihydropyridine-derived calcium channel blocker developed in Japan, with several unique mechanisms of action, that is, triple calcium channels (L, N, and T) blocking action with a membrane approach. Benidipine has relatively high vascular selectivity and is expected to show protective effects on vascular endothelial cells. Renal protective effects of benidipine also have been shown in several basic and clinical studies. Moreover, anti-oxidative action and enhancing nitric oxide production have been noted with this drug, following its cardio-protective effects in patients with ischemic heart diseases. In fact, benidipine exerted a better prognostic effect than other calcium channel blockers in the therapy for patients with vasospastic angina. In addition, benidipine showed reliable antihypertensive, renoprotective effects if used in combination with angiotensin II type 1 receptor blockers (ARBs) when adequate anti-hypertensive effects are not achieved by ARBs alone, indicating that benidipine is an useful calcium channel blocker in combination therapy for hypertension. Benidipine was launched on the Japanese market 14 years ago, but few severe side effects have been reported, suggesting that this is a drug with established safety and long-acting pharmacological effects.

著者

Katsutoshi MIZUNO Masafumi OGATA Ken NAGASHIMA

出版者

公益財団法人 鉄道総合技術研究所

雑誌

Quarterly Report of RTRI (ISSN:00339008)

巻号頁・発行日

vol.54, no.1, pp.46-51, 2013-02-01 (Released:2013-03-06)

参考文献数

5

被引用文献数

4 7

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YBCO coated conductors attract attention because of their high critical current in high magnetic field conditions, hence calling for a suitable coil fabrication method. One of the critical problems associated with this process, however, is the negative impact on YBCO coil performance due to epoxy impregnation. Epoxy impregnation is an important technique to increase the mechanical strength and thermal conductivity of superconducting coils. However, the bonding strength of epoxy resin is stronger than the delamination strength of YBCO coated conductors in a certain direction. Therefore, thermal stress could damage epoxy impregnated YBCO coils. As a new impregnation material, we have focused on cyanoacrylate resin.