著者

牧野 公子 Mack Eric. J. 岡野 光夫 Kim Sung. Wan.

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.7, no.3, pp.191-195, 1992

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Hydrophilic nylon microcapsules containing concanavalin A and succinyl-amidophenyl-glucopyranoside insulin (SAPG-insulin), whose average diameter was 70 <I>γ</I>m were prepared to achieve a self-regulating insulin delivery system. The microcapsules were enclosed in polymer membranes for <I>in vitro</I> assessment and the release of SAPG-insulin was evaluated under a flow condition of glucose solution. The amount and the rate of SAPG-insulin released from this pouch were dependent upon the external glucose concentration around the pouch. Also, SAPG-insulin was quickly released from a pouch in response to the change of the external glucose concentration. In addition, to optimize this self regulating insulin delivery system, we studied the kinetics of solute permeation through a membrane separating two compartments : donor and receiver under the condition that the receiver compartment was continuously eluted.